{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:13:13Z","timestamp":1775787193006,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T00:00:00Z","timestamp":1155686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic> is implicated in the etiology of gastric and duodenal ulcer, non\u2010ulcer dispepsia, atrophic gastritis, gastric adenocarcinoma and lymphoma.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Between November 1995 and December 2004, the presence of <jats:italic>H.\u2003pylori<\/jats:italic> was investigated using the CLO test in 9239 patients who underwent upper gastrointestinal endoscopy at a single institution in Istanbul, Turkey. The results were evaluated as early\u2013late positive, and negative.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There were 4667 women (50.51%) with a mean age of 44.5\u2003years (range, 13\u201390\u2003years), and 4572 men (49.49%) with a mean age of 45.7\u2003years (range, 11\u201385\u2003years). The CLO test was positive in 41.44% of cases. The most frequent symptoms on admission were epigastric pain (46.2%) and burning (19.6%). The most frequent endoscopic diagnosis was pangastritis (64%) and non\u2010erosive duodenitis (30.5%). The <jats:italic>H.\u2003pylori<\/jats:italic> positivity was 61.53% during the first 5\u2010year period and 38.47% during the second 5\u2010year period. The <jats:italic>H.\u2003pylori<\/jats:italic> positivity was significant in patients using non\u2010steroidal anti\u2010inflamatory drugs and tobacco (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Discussion and Conclusion:\u2002<\/jats:bold>  <jats:italic>Helicbacter pylori<\/jats:italic> prevelance remains an important health problem for Turkey although it has diminished in parallel to the national development during the last years. <jats:italic>Helicbacter pylori<\/jats:italic>, as a first\u2010degree carcinogen, should be investigated and eradicated particularly in high\u2010risk patients.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04610.x","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T18:17:11Z","timestamp":1157739431000},"page":"1706-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Endoscopic diagnoses and CLO test results in 9239 cases, prevalence of <i>Helicobacter pylori<\/i> in Istanbul, Turkey"],"prefix":"10.1111","volume":"22","author":[{"given":"Yavuz Selim","family":"Sar\u0131","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersan","family":"Sander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esin","family":"Erkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahit","family":"Tunal\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00770.x"},{"key":"e_1_2_5_3_2","first-page":"60","article-title":"The spectrum of helicobacter pylori in upper gastrointestinal disease","volume":"62","author":"Velonich V","year":"1996","journal-title":"Am. 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