{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:35:46Z","timestamp":1778002546731,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T00:00:00Z","timestamp":1155686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Anti\u2010inflammatory cytokines play an important role in downregulation of inflammation and the prevention of neoplastic disorders. Genetic variations of anti\u2010inflammatory cytokines are assumed to influence such responses. The aim of the present study was to clarify the association between the <jats:italic>IL\u201010<\/jats:italic> polymorphism, one of the representative anti\u2010inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The <jats:italic>IL\u201010\u2010<\/jats:italic>1082 (A\/G)\/\u2010819 (T\/C)\/\u2010592 (A\/C) polymorphisms were assessed in <jats:italic>Helicobacter pylori<\/jats:italic>\u2010positive patients with gastritis only (<jats:italic>n<\/jats:italic>\u2003=\u2003162), gastric ulcers (<jats:italic>n<\/jats:italic>\u2003=\u2003110), duodenal ulcers (<jats:italic>n<\/jats:italic>\u2003=\u200394), or gastric cancers (<jats:italic>n<\/jats:italic>\u2003=\u2003105), and <jats:italic>H.\u2003pylori<\/jats:italic>\u2010negative controls (<jats:italic>n<\/jats:italic>\u2003=\u2003168) by allele specific primer\u2013polymerase chain reaction methods.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The carriage of <jats:italic>IL\u201010\u2010<\/jats:italic>592 C (age and sex\u2010adjusted odds ratio [OR]: 1.851, 95% confidence interval [CI]: 1.018\u20133.380) and <jats:italic>IL\u201010\u2010<\/jats:italic>819 C (adjusted OR: 1.868, 95%CI: 1.023\u20133.411) allele were associated with an increased risk for gastric cancer development, not gastric ulcer and duodenal ulcer. The <jats:italic>IL\u201010<\/jats:italic>\u20101082 polymorphism had no association with development of gastric cancer and peptic ulcers. The presence of the ATA\/GCC haplotype of <jats:italic>IL\u201010<\/jats:italic>\u20101082\/\u2010819\/\u2010592 polymorphism significantly increased the risk of gastric cancer development (adjusted OR: 2.805, 95%CI: 1.258\u20136.254) compared with presence of the ATA\/ATA haplotype.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The <jats:italic>IL\u201010<\/jats:italic>\u20101082\/\u2010819\/\u2010592 genotype status and haplotype were associated with an increased risk for gastric cancer development, not peptic ulcer, in Japan. The genotyping test of this anti\u2010inflammatory cytokine would be useful for the detection of individuals with higher risk of gastric cancer development.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04613.x","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T18:17:11Z","timestamp":1157739431000},"page":"1443-1449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Effects of interleukin\u201010 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects"],"prefix":"10.1111","volume":"22","author":[{"given":"Mitsushige","family":"Sugimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohito","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Kajimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91409-F"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34156"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02678.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00899-0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28000"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000108315.52416.bf"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01593.x"},{"key":"e_1_2_6_11_2","first-page":"107","article-title":"[Role of polymorphism of certain cytokines in gastric cancer in Mexico. Preliminary results]","volume":"68","author":"Garza\u2010Gonzalez E","year":"2003","journal-title":"Rev. Gastroenterol. Mex."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/35006081"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00157-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.029736"},{"issue":"11","key":"e_1_2_6_15_2","first-page":"10","article-title":"Relation between interleukin\u20101beta messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori","volume":"34","author":"Wang M","year":"1999","journal-title":"J. Gastroenterol."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.4.442"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8964399"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.6.739"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.8.4802-4804.2000"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70134-X"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.1997.tb00001.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540408.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05926.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg420"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022060"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.10.013"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10987"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh349"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1281-x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2004.11.038"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.41.183"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00130.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.4.665"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200210-1164OC"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363657"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:3<590::AID-ANR37>3.0.CO;2-9"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.11.3941.423k10_3941_3946"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-003-0621-6"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1086\/322987"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.6.3915"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90360-B"},{"key":"e_1_2_6_44_2","first-page":"G966","article-title":"Interleukin\u20101 beta inhibits gastric histamine secretion and synthesis in the rat","volume":"267","author":"Kondo S","year":"1994","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.11.028"},{"key":"e_1_2_6_46_2","article-title":"Different effects of polymorphisms of tumor necrosis factor\u2010alpha and interleukin\u20101 beta on development of peptic ulcer and gastric cancer","author":"Sugimoto M","journal-title":"J. Gastroenterol. Hepatol."},{"key":"e_1_2_6_47_2","first-page":"1916","article-title":"Glutathione S\u2010transferase M1 gene null genotype and gastric cancer risk in Taiwan","volume":"52","author":"Lai KC","year":"2005","journal-title":"Hepatogastroenterology"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1746.2006.04613.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1746.2006.04613.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T23:34:27Z","timestamp":1697326467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1746.2006.04613.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,15]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1111\/j.1440-1746.2006.04613.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1746.2006.04613.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,15]]},"assertion":[{"value":"2007-08-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}