{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:23:32Z","timestamp":1768011812331,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T00:00:00Z","timestamp":1159401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Reflux symptom assessment had reliable accuracy in the diagnosis of gastroesophageal reflux disease (GERD). However, patients may recognize heartburn or regurgitation as dyspepsia because of inaccurate understanding or atypical presentation. The aim of the present study was to estimate endoscopic reflux esophagitis in patients with upper abdominal pain as a predominant symptom in the absence of heartburn or regurgitation.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Two hundred and sixty\u2010three consecutive patients presenting dyspepsia without heartburn or regurgitation were enrolled. Patients with heartburn or regurgitation were excluded using the symptom interviewer method. Dyspepsia was categorized into pain\u2010predominant or dysmotility\u2010predominant groups according to the Rome II proposal. Endoscopic reflux esophagitis was graded using the Los Angeles classification.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> One hundred and five patients were included in the pain\u2010predominant group and 119 in the dysmotility\u2010predominant group. Reflux esophagitis was found in 18.8% (42\/224) of all dyspeptic patients. Grade A esophagitis was noted in 27.6% (29\/105) of the pain\u2010predominant group and in 7.6% (9\/119) of the dysmotility\u2010predominant group. Grade B was noted in two patients in each group. A total of 29.5% (31\/105) and 9.3% (11\/119) had reflux esophagitis, respectively (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Comparing patients with or without reflux esophagitis, there was no difference in body mass index, smoking habit, alcohol consumption, or <jats:italic>Helicobacter pylori<\/jats:italic> infection status.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> A significant proportion of patients presenting dyspepsia, especially pain\u2010predominant dyspepsia, have endoscopic reflux esophagitis. In view of GERD, pain\u2010predominant dyspepsia should be investigated and managed differently from dysmotility\u2010predominant dyspepsia.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04678.x","type":"journal-article","created":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T09:55:13Z","timestamp":1159437313000},"page":"2217-2221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Endoscopic reflux esophagitis in patients with upper abdominal pain\u2010predominant dyspepsia"],"prefix":"10.1111","volume":"22","author":[{"given":"Ho June","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee Don","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwoon\u2010Yong","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gin Hyug","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yun","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Sik","family":"Byeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk\u2010Kyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weon\u2010Seon","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii37"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655298750026697"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1993.tb00073.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.034280"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01646.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03451.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01026.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03776.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90287-F"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.034355"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02148.x"},{"key":"e_1_2_5_14_2","first-page":"668","article-title":"The incidence of reflux esophagitis among the Chinese","volume":"92","author":"Chang CS","year":"1997","journal-title":"Am. 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