{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:17:03Z","timestamp":1789942623964,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Choline deficient (CD) and methione\u2010choline deficient (MCD) diets are rodent models for steatosis, with potentially dissimilar biochemical backgrounds. The aim of this study was to assess the metabolic and pathological derangements in rats fed CD and MCD diets.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Male Wistar rats received CD or MCD diet up to 7\u2003weeks. Nutritional status, liver histopathology, Kupffer cell\u2010mediated inflammation and injury, oxidative stress via thiobarbituric reactive species (TBARS), hepatic and plasma glutathione (GSH) and insulin homeostasis were assessed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In CD\u2010fed rats, mainly microvesicular steatosis developed with occasional inflammatory cells. In MCD\u2010fed rats, macrovesicular steatosis progressed to steatohepatitis (collagen deposition, activated stellate cells). Hepatic TBARS was increased and GSH decreased in the MCD\u2010fed rats compared to no changes in the CD\u2010fed rats. The CD\u2010fed rats developed obesity, dyslipidemia and insulin resistance, in contrast to undetectable plasma lipids, unaffected insulin homeostasis and loss of body weight in the MCD\u2010fed rats.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The CD diet induced uncomplicated steatosis as compared to progressive inflammation and fibrinogenesis in the MCD diet. CD and MCD diets represent two pathogenically different models of steatosis. Although equivalence for the outcome of both diets can be found in clinical steatosis, the results of models using these diets should be compared with caution.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04701.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T06:09:35Z","timestamp":1161151775000},"page":"1526-1533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Essential pathogenic and metabolic differences in steatosis induced by choline or methione\u2010choline deficient diets in a rat model"],"prefix":"10.1111","volume":"22","author":[{"given":"Reeta","family":"Vetel\u00e4inen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arl\u00e8ne","family":"Van Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Van Gulik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"59","article-title":"Prevalence of fatty liver in healthy male adults accidentally killed","volume":"55","author":"Underwood G","year":"1984","journal-title":"Aviat. 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