{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T19:30:43Z","timestamp":1769628643626,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The aim of this study was to compare the acceptance and tolerance of transnasal and peroral esophagogastroduodenoscopy (EGD) using an ultrathin videoendoscope in unsedated patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 124 patients referred for diagnostic endoscopy were assigned randomly to have an unsedated transnasal EGD (<jats:italic>n<\/jats:italic>\u2003=\u200364) or peroral EGD (<jats:italic>n<\/jats:italic>\u2003=\u200360) with local anesthesia. An ultrathin videoendoscope with a diameter of 5.9\u2003mm was used in this study. A questionnaire for tolerance was completed by the patient (a validated 0\u201310 scale where \u20180\u2019 represents no discomfort\/well tolerated and \u201810\u2019 represents severe discomfort\/poorly tolerated).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the 64 transnasal EGD patients, 60 patients (94%) had a complete examination. Four transnasal EGD examinations failed for anatomical reasons; all four patients were successfully examined when switched to the peroral EGD. All 60 peroral EGD patients had a complete examination. Between the transnasal and peroral groups, there was a statistically significant difference in scores for discomfort during local anesthesia (1.5\u2003\u00b1\u20030.2 <jats:italic>vs<\/jats:italic> 2.6\u2003\u00b1\u20030.3, <jats:italic>P<\/jats:italic>\u2003=\u20030.003), discomfort during insertion (2.3\u2003\u00b1\u20030.3 <jats:italic>vs<\/jats:italic> 4.3\u2003\u00b1\u20030.3, <jats:italic>P<\/jats:italic>\u2003=\u20030.001), and overall tolerance during procedure (1.6\u2003\u00b1\u20030.2 <jats:italic>vs<\/jats:italic> 3.8\u2003\u00b1\u20030.2, <jats:italic>P<\/jats:italic>\u2003=\u20030.001). In all, 95% of transnasal EGD patients and 75% of peroral EGD patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.002) were willing to undergo the same procedure in the future. Four patients in the transnasal EGD group experienced mild epistaxis.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> For unsedated endoscopy using an ultrathin videoendoscope, transnasal EGD is well tolerated and considerably reduces patient discomfort compared with peroral EGD.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2006.04730.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T06:09:35Z","timestamp":1161151775000},"page":"482-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Prospective randomized trial of transnasal versus peroral endoscopy using an ultrathin videoendoscope in unsedated patients"],"prefix":"10.1111","volume":"22","author":[{"given":"Atsuhiko","family":"Murata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Akahoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorinobu","family":"Sumida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Nawata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2002.123274"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70092-5"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171747"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(94)70068-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00406.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(89)72712-7"},{"key":"e_1_2_5_8_2","first-page":"411","article-title":"Endoscopy: throat spray or sedation?","volume":"28","author":"Pereira SP","year":"1994","journal-title":"J. R. Coll. Physicians Lond."},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70001-5"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70002-7"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70003-9"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70004-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1005504"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2003.59"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41523"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41513"},{"key":"e_1_2_5_17_2","first-page":"S13","article-title":"1989 ASGE survey of endoscopic sedation and monitoring practices","volume":"36","author":"Keeffe EB","year":"1990","journal-title":"Gastrointest. Endosc."},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.1.12"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.3.462"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1008949"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90441-7"},{"key":"e_1_2_5_22_2","first-page":"533","article-title":"Arterial oxygen saturation in sedated patients undergoing gastrointestinal endoscopy and a review of pulse oximetry","volume":"61","author":"Visco DM","year":"1989","journal-title":"Del. Med. J."},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658972"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1746.2006.04730.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1746.2006.04730.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T23:57:12Z","timestamp":1697327832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1746.2006.04730.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,20]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1111\/j.1440-1746.2006.04730.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1746.2006.04730.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,20]]},"assertion":[{"value":"2007-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}