{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T14:56:30Z","timestamp":1773672990138,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T00:00:00Z","timestamp":1181174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> A beneficial effect of <jats:italic>Helicobacter pylori (H.\u2003pylori)<\/jats:italic> eradication in patients with <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive idiopathic thrombocytopenic purpura (ITP) has been reported by several investigators; however, it was not clear whether the recovered platelet count after <jats:italic>H.\u2003pylori<\/jats:italic> eradication was maintained for a long period.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Thirty\u2010eight ITP patients who were examined for <jats:italic>H.\u2003pylori<\/jats:italic> infection were assessed. <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive patients received a standard antibiotic therapy for <jats:italic>H.\u2003pylori<\/jats:italic> eradication. We investigated the long\u2010term effect of <jats:italic>H.\u2003pylori<\/jats:italic> eradication on platelet recovery in patients with <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive ITP.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the 38 ITP patients, 26 (68.4%) were positive for <jats:italic>H.\u2003pylori<\/jats:italic>. The response rate of platelet recovery was 56.5% (13\/23 patients). Twelve patients showed complete response (CR) and one showed partial response (PR). The mean platelet counts 6\u2003months after eradication significantly increased from 31\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L to 129\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L in 23 <jats:italic>H.\u2003pylori<\/jats:italic>\u2010eradicated patients (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.001). The median platelet counts of responders 1, 2, 3, and 4\u2003years after eradication were 168\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L (<jats:italic>n<\/jats:italic>\u2003=\u200310), 193\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L (<jats:italic>n<\/jats:italic>\u2003=\u20039), 168\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L (<jats:italic>n<\/jats:italic>\u2003=\u20037), and 243\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L (<jats:italic>n<\/jats:italic>\u2003=\u20034) after a mean follow\u2010up of 25.8\u2003months.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Eradication therapy for <jats:italic>H.\u2003pylori<\/jats:italic>\u2010positive patients with ITP was effective and a favorable effect was maintained for long periods.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2007.04845.x","type":"journal-article","created":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T11:43:19Z","timestamp":1181216599000},"page":"2233-2237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The long\u2010term efficacy of <i>Helicobacter pylori<\/i> eradication therapy in patients with idiopathic thrombocytopenic purpura"],"prefix":"10.1111","volume":"22","author":[{"given":"Masaaki","family":"Satake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Fukagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoharu","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuyoshi","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Maetani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youzou","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Sakaida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"16","author":"Marshall BJ","year":"1984","journal-title":"Lancet"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00537.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302043280503"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322501"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005350300061"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.187"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709025109"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050385"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60004-9"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.1.3.3"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.3.812"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00261.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03612.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00277-002-0579-8","article-title":"Platelet recovery after eradication of Helicobacter pylori in patients with idiopathic thrombocytopenic purpura","volume":"82","author":"Hino M","year":"2003","journal-title":"Ann. 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