{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T01:30:33Z","timestamp":1721093433693},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T00:00:00Z","timestamp":1181174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Upper gastrointestinal symptoms, mainly dyspepsia, are common adverse effects in patients under highly active antiretroviral therapy (HAART). Whether it is worthwhile to perform endoscopy early in their treatment is a matter of debate. We have done a prospective study of the prevalence and the etiology of endoscopic lesions in a large cohort of dyspeptic adult HIV\u2010infected patients under HAART, according to their immunological status.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> 528 (334 men and 194 women, mean age 38) HIV\u2010infected patients under HAART with epigastric pain and\/or nausea and vomiting underwent upper endoscopy. Patients were classified in two groups, according to CD4 cells counting (&gt;200 cells\/mm<jats:sup>3<\/jats:sup> or \u2264200 cells\/mm<jats:sup>3<\/jats:sup>). Gastric and duodenal biopsies were taken from normal mucosa and any lesion found.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Gastric mucosa alterations were seen in 61.74% of patients (40.71% erythema, 18.38% erosion and 2.65% ulcer). Duodenum mucosa alterations were seen in 25.37% of patients, mainly erosions (19.50%) and ulcer (3.59%). There was no difference in endoscopic findings according to CD4 cell count groups. Chronic active gastritis was shown in 459 patients (86.93%). <jats:italic>H. pylori<\/jats:italic> infection was seen in 32.38%, and it was more prevalent in the group with CD4\u2003&gt;\u2003200 (p\u2003&lt;\u20030.01). Opportunistic infections and malignancies were seen exclusively in patients with CD4\u2003\u2264\u2003200.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Most of the endoscopic lesions in dyspeptic HIV\u2010infected patients under HAART were not related to AIDS. Upper endoscopy was more helpful in dictating clinical treatment in patients with low CD4 counts (\u2264200) and should be done earlier in this group.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2007.04897.x","type":"journal-article","created":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T07:34:01Z","timestamp":1181201641000},"page":"1712-1716","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dyspepsia in HIV\u2010infected patients under highly active antiretroviral therapy"],"prefix":"10.1111","volume":"22","author":[{"given":"Ana Luiza","family":"Werneck\u2013Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivete Bedin","family":"Prado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/324354"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200003310-00005"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00126334-200102010-00016","article-title":"Reasons for discontinuation of first highly active antiretroviral therapy in a cohort of proteinase inhibitor\u2010na\u00efve HIV\u2010infected patients","volume":"26","author":"H\u00e4nsel A","year":"2001","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912163412501"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.suppl_4.iv13"},{"key":"e_1_2_5_7_2","first-page":"1576","article-title":"Helicobacter pylori infection in patients with acquired immune deficiency syndrome","volume":"85","author":"Battan R","year":"1990","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_5_8_2","first-page":"687","article-title":"Helicobacter pylori prevalence in acquired immunodeficiency syndrome","volume":"88","author":"Marano BJ","year":"1993","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_5_9_2","first-page":"1783","article-title":"Lower Helicobacter pylori infection and peptic ulcer disease prevalence in patients with AIDS and supressed CD4 counts","volume":"91","author":"Cacciarelli AG","year":"1996","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00282.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2003.03278.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-004-9580-5"},{"key":"e_1_2_5_13_2","first-page":"79","article-title":"Helicobacter pylori in Indian HIV infected patients","volume":"23","author":"Sud A","year":"2002","journal-title":"Trop. Gastroenterol."},{"key":"e_1_2_5_14_2","first-page":"226","article-title":"Prevalence of Helicobacter pylori and endoscopic findings in seropositive patients with upper gastrointestinal tract symptoms at Kenyatta National Hospital, Nairobi","volume":"79","author":"Alimohamed F","year":"2002","journal-title":"East Afr. Med. J."},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02854-3"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.988"},{"key":"e_1_2_5_17_2","first-page":"199","article-title":"Helicobacter pylori infection in a group of HIV\/AIDS patients","volume":"53","author":"Alonso LJ","year":"2001","journal-title":"Rev. Cubana Med. Trop."},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.029736"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.615"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/35083631"},{"key":"e_1_2_5_21_2","first-page":"89","article-title":"Highly active antiretroviral therapy and opportunistic protozoan infections","volume":"46","author":"Pozio E","year":"2004","journal-title":"Parassitologia"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(03)00048-0"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.4.229"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899809029932"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101200100015"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1746.2007.04897.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1746.2007.04897.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T21:13:27Z","timestamp":1697318007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1746.2007.04897.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,2]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1111\/j.1440-1746.2007.04897.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1746.2007.04897.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,2]]},"assertion":[{"value":"2007-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}