{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:45:10Z","timestamp":1773269110273,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7pt2","license":[{"start":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T00:00:00Z","timestamp":1188172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Chronic liver failure results in the decrease of the number of functioning hepatocytes. It dictates the necessity of using exogenous viable cells or\/and agents that can stimulate hepatic regenerative processes. Fetal liver contains both hepatic and hematopoietic stem cells with high proliferative potential, which may replace damaged cells. Also, immature cells produce fetal\u2010specific factors which may support the injured liver. Our aim was to test the ability of human fetal liver cells and cell\u2010free fetal\u2010specific factors of non\u2010hepatic origin to stimulate recovery processes in an experimental model of carbon tetrachloride\u2013induced cirrhosis in rats.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Cirrhotic rats were intrasplenically injected with fetal liver cells (1\u2003\u00d7\u200310<jats:sup>7<\/jats:sup> cells\/0.3\u2003mL medium) or cell\u2010free fetal\u2010specific factors (0.3\u2003mL\/1\u2003mg protein). Control groups received medium alone. Serum indexes, hepatic functions, and morphology were evaluated for 15\u2003days.<\/jats:p><jats:p><jats:bold>Result:\u2002<\/jats:bold> Human fetal liver cell transplantation was shown to abrogate the mortality of cirrhotic animals, to improve serum markers, and to restore liver mitochondrial function and detoxification. Morphological patterns of liver recovery were observed by histology. In comparison, an injection of fetal\u2010specific factors produced similar functional recovery, whilst a more limited liver regeneration was observed by histology.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The positive effects of fetal liver cell and cell\u2010free fetal\u2010specific factors in experimental cirrhosis may result from the presence of stage\u2010specific factors activating hepatocellular repair.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2007.05095.x","type":"journal-article","created":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T06:57:20Z","timestamp":1188284240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Functional hepatic recovery after xenotransplantation of cryopreserved fetal liver cells or soluble cell\u2010factor administration in a cirrhotic rat model: Are viable cells necessary?"],"prefix":"10.1111","volume":"23","author":[{"given":"Olga V","family":"Ochenashko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurii V","family":"Nikitchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya A","family":"Volkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana P","family":"Mazur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y","family":"Somov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry J","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y","family":"Petrenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3748\/wjg.v6.i5.636","article-title":"Transplantation of primary and reversibly immortalized human liver cells and other gene therapies in acute liver failure and decompensated chronic liver disease","volume":"6","author":"Riordan S","year":"2000","journal-title":"World J. 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