{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:16:24Z","timestamp":1793236584345,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> There are limited data on response and long\u2010term follow\u2010up of octreotide therapy in type\u2010I gastric neuroendocrine tumors. The objective of the present study was to assess the response of type\u2010I gastric neuroendocrine tumors to octreotide\u2010long acting, repeatable (LAR) therapy and evaluate long\u2010term follow up of such patients after therapy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Three patients with documented type\u2010I gastric neuroendocrine tumors from a tertiary gastroenterology centre were studied. Octreotide\u2010LAR therapy 20\u2003mg intramuscularly every 28\u2003days was administered for one year. Serum gastrin and chromogranin levels, gastroscopies and biopsies from tumor nodules at 6\u2003months and one year on therapy and every 6\u2003months after completion of drug therapy were taken. Follow\u2010up after completion of therapy extended for 3\u2003years in two and 2.5\u2003years in one patient.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> During octreotide therapy there was normalization of serum gastrin levels and serum chromogranin levels. Tumors in all three patients had regressed at 6\u2003months of treatment. Following cessation of therapy, there was progressive rise of serum gastrin to pre\u2010treatment levels. Serum chromogranin levels remained within normal limits. Gastroscopic and histologic examination of gastric biopsies did not reveal recurrence of tumors in any patients. All patients tolerated therapy well and became asymptomatic soon after drug therapy.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Octreotide\u2010LAR therapy causes regression of type\u2010I gastric neuroendocrine tumors. After completion of drug therapy there was no recurrence of tumors even with continued hypergastrinemia. Octreotide therapy should be considered as one of the treatment options in such patients.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2009.06131.x","type":"journal-article","created":{"date-parts":[[2010,1,14]],"date-time":"2010-01-14T05:10:45Z","timestamp":1263445845000},"page":"548-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Treatment of type I gastric neuroendocrine tumors with somatostatin analogs"],"prefix":"10.1111","volume":"25","author":[{"given":"Mehnaaz Sultan","family":"Khuroo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Sultan","family":"Khuroo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naira Sultan","family":"Khuroo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401107"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970215)79:4<813::AID-CNCR19>3.0.CO;2-2"},{"key":"e_1_2_5_4_2","first-page":"338","article-title":"Gastric carcinoid tumors: the biology and therapy of an enigmatic and controversial lesion","volume":"90","author":"Gilligan CJ","year":"1995","journal-title":"Am. 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