{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:43:11Z","timestamp":1792633391230,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2010,4,23]],"date-time":"2010-04-23T00:00:00Z","timestamp":1271980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aims:\u2002<\/jats:bold> According to reports in Japanese patients, 1\u2003week of <jats:italic>Helicobacter pylori<\/jats:italic> eradication therapy alone is not adequate for healing of gastric ulcers; 7\u20138\u2003weeks of anti\u2010ulcer therapy are subsequently required. We compared a gastroprotective drug, sofalcone, and an H<jats:sub>2<\/jats:sub>\u2010receptor antagonist, cimetidine, in terms of promoting ulcer healing after 7\u2003weeks of administration following 1\u2003week of eradication therapy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Eradication therapy was administered to 64 patients with <jats:italic>H. pylori<\/jats:italic>\u2010positive active gastric ulcer at least 10\u2003mm in diameter, after which 32 patients each received 7\u2003weeks of ulcer treatment with sofalcone (300\u2003mg\/day) or cimetidine (800\u2003mg\/day).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The <jats:italic>H. pylori<\/jats:italic> eradication rate was 81.3% (intention\u2010to\u2010treat: ITT) and 81.3% (per protocol: PP) in the sofalcone group, and 62.5% (ITT) and 64.5% (PP) in the cimetidine group. The ulcer healing rate after 8\u2003weeks was 71.9% (ITT) and 71.9% (PP) in the sofalcone group, and 71.9% (ITT) and 71.0% (PP) in the cimetidine group. The rate of a flat pattern of scarred mucosa was 43.5% (ITT) and 43.5% (PP) in the sofalcone group, and 47.8% (ITT) and 50.0% (PP) in the cimetidine group. No significant differences were seen between the two groups in terms of <jats:italic>H. pylori<\/jats:italic> eradication rate, ulcer healing rate and flat pattern rate.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Sofalcone promoted gastric ulcer healing during 7\u2003weeks of treatment following 1\u2003week of eradication therapy, and the healing rate was equivalent to that of cimetidine. Symptom disappearance rates were significantly better in the sofalcone group than in the cimetidine group. This may be a useful way of using a gastroprotective drug in the <jats:italic>H. pylori<\/jats:italic> era.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2010.06232.x","type":"journal-article","created":{"date-parts":[[2010,4,23]],"date-time":"2010-04-23T11:04:02Z","timestamp":1272020642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for <i>Helicobacter pylori:<\/i> A randomized controlled comparative trial with cimetidine, an H<sub>2<\/sub>\u2010receptor antagonist"],"prefix":"10.1111","volume":"25","author":[{"given":"Kazuhide","family":"Higuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Tanigawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302043280503"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-9-705"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613015"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320302"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01402.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2076-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199206001-00007"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90026-9"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90155-X"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1997.tb00393.x"},{"key":"e_1_2_5_12_2","first-page":"99","article-title":"Rebamipide prevents recurrence of gastric ulcers without affecting Helicobacter pylori status","volume":"43","author":"Higuchi K","year":"1998","journal-title":"Dig. 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