{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:11:50Z","timestamp":1697440310784},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T00:00:00Z","timestamp":1277251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstracts<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> This study attempted to clarify accuracy of acute hepatitis C (AHC) and its clinical characteristics.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We reviewed 632 reported cases from national surveillance data of the Taiwan Center for Disease Control between 1995 and 2004, and reclassified diagnoses. A definite case was defined as alanine aminotransferase (ALT)\u2003&gt;\u200310\u2003\u00d7 the upper limit of normal (ULN) with seroconversion of anti\u2010hepatitis C virus antibody (anti\u2010HCV). A probable case was defined as (i) seroconversion of anti\u2010HCV and\/or elevated ALT levels; or (ii) anti\u2010HCV(+) but titers increased (from &lt;\u200340\u2003S\/CO to \u2265\u200340\u2003S\/CO) and ALT\u2003&gt;\u200310\u2003\u00d7 the ULN. A suspected case was defined as initial anti\u2010HCV(+) and ALT level\u2003&gt;\u200310\u2003\u00d7 the ULN and\/or jaundice. Excluded cases were defined as ALT levels less than 10\u2003\u00d7 ULN with initial positive anti\u2010HCV Ab.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A total of 310 (49%) cases were confirmed as AHC; these included 95 (15%) definite and 215 (34%) probable cases. Higher incidence rates and accuracy of AHC were demonstrated in the southern area significantly if compared with northern, eastern and central areas, respectively (all <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). On comparison between blood centers and hospitals, more AHC cases were found in Southern Taiwan than in other areas (157\/73 vs 24\/40, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), younger mean age (33.3\u2003\u00b1\u200311.1 vs 49.3\u2003\u00b1\u200316.4, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), lower ALT levels (263.1\u2003\u00b1\u2003200.9 vs 1264.2\u2003\u00b1\u2003706.8, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and male predominance (191\/39 vs 46\/18, <jats:italic>P<\/jats:italic>\u2003=\u20030.046).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This study showed our reporting system over\u2010estimated the AHC diagnosis, which is also a common issue worldwide. Greater efforts are needed to establish appropriate reporting systems, as well as more supplemental methods to distinguish between prevalent and incident cases.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2010.06236.x","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T07:15:31Z","timestamp":1277277331000},"page":"1289-1294","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low accuracy of the national reporting system of acute hepatitis C infection in Taiwan, 1995\u20132004"],"prefix":"10.1111","volume":"25","author":[{"given":"Kwong\u2010Ming","family":"Kee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Ming","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Houng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Hung","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pao\u2010Fei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Sin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Nan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,23]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15109-4"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70216-4"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5762"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210306"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2008.01.049"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212313272702"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61116-2"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01825.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21902"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/429490"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.10.017"},{"key":"e_1_2_8_13_2","doi-asserted-by":"crossref","first-page":"pii: 18879","DOI":"10.2807\/ese.13.21.18879-en","article-title":"Acute hepatitis C virus infection","volume":"13","author":"Irving WL","year":"2008","journal-title":"Euro Surveill."},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37897424409.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(99)00146-9"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310002526"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2008.01009.x"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2004.00533.x"},{"key":"e_1_2_8_19_2","unstructured":"Health Protection Agency Annual Report.Hepatitis C in England: an update 2007. 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