{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:16:27Z","timestamp":1770819387364,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T00:00:00Z","timestamp":1290470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold>Contemporary medications used in the treatment of gastric ulcers involve the use of novel mucosal protective drugs. The present study aimed to investigate the gastroprotective effect of ginger extract and polaprezinc in a rat model of acetic acid\u2010induced gastric ulcer.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>\u2018Kissing\u2019 ulcers were induced in male Sprague\u2010Dawley rats by using 60% acetic acid.<jats:italic>Rhizoma Zingiber officinale<\/jats:italic>(ginger) extract (1.5\u20135\u2003g\/kg) or polaprezinc (30 and 60\u2003mg\/kg) was orally given to the animals once daily for three consecutive days after ulcer induction. All animals were killed on day 5 by an overdose of ketamine.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Both ginger extract and polaprezinc significantly reduce the gastric ulcer area in a dose\u2010dependent manner, with concomitant attenuation of the elevated activities of xanthine oxidase and myeloperoxidase, as well as malondialdehyde level in the ulcerated mucosa. Nevertheless, only polaprezinc could restore the mucosal glutathione level. Polaprezinc also causes the overexpression of basic fibroblast growth factor, vascular endothelial growth factor and ornithine decarboxylase, whereas ginger extract only increases the expression of the two growth factors in the gastric mucosa. Furthermore, polaprezinc could consistently downregulate the protein expression of tumor necrosis factor (TNF)\u2010\u03b1, interleukin\u20101\u03b2, macrophage inflammatory protein\u20102 and cytokine\u2010induced neutrophil chemoattractant\u20102\u03b1 that have been activated in the ulcerated tissues, whereas ginger extract mainly inhibits the expression of the chemokines and to some extent TNF\u2010\u03b1.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>Ginger extract and polaprezinc both show anti\u2010oxidation that consequently alleviates gastric mucosal damage and promotes ulcer healing, which together serve as effective mucosal protective agents.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2010.06347.x","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T09:29:55Z","timestamp":1270718995000},"page":"1861-1869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Ginger extract and polaprezinc exert gastroprotective actions by anti\u2010oxidant and growth factor modulating effects in rats"],"prefix":"10.1111","volume":"25","author":[{"given":"Joshua K","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine C","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(88)90009-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X89000097"},{"issue":"5","key":"e_1_2_6_4_2","first-page":"3699","article-title":"Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori","volume":"23","author":"Mahady GB","year":"2003","journal-title":"Anticancer Res."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.9.7.1537"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091161"},{"key":"e_1_2_6_7_2","first-page":"127","article-title":"Possible role of zinc in the healing process of chronic ulcer in rats","volume":"20","author":"Anti H","year":"1993","journal-title":"Ulcer Res."},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00078-7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00408.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1992.tb03623.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.67.271"},{"issue":"11","key":"e_1_2_6_12_2","first-page":"43","article-title":"Polaprezinc, a gastroprotective agent: attenuation of monochloramine\u2010evoked gastric DNA fragmentation","volume":"34","author":"Suzuki H","year":"1999","journal-title":"J. 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