{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:43:51Z","timestamp":1755693831773},"reference-count":19,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T00:00:00Z","timestamp":1301270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence for an association between <jats:italic>H. pylori<\/jats:italic> and functional dyspepsia (FD) is uncertain. In the present review, we focused the special relevance of <jats:italic>H. pylori<\/jats:italic> infection to the development dyspepsia from the aspects of pathogensis, clinical efficacy of eradication of <jats:italic>H. pylori<\/jats:italic> in the West and in the East. Although clinical trials conducted to evaluate the efficacy of <jats:italic>H. pylori<\/jats:italic> eradication treatment for FD, including non\u2010ulcer dyspepsia (NUD), have yielded conflicting results, it is quite clear that <jats:italic>H. pylori<\/jats:italic> eradication treatment is effective at least in a subset of FD patients. In contrast to the previous results obtained in studies of Western populations, the result of a double\u2010blind, randomized, placebo\u2010controlled trial conducted in a Singapore suggests that patients with FD could benefit from <jats:italic>H. pylori<\/jats:italic> eradication therapy, with as much as a 13\u2010fold increase in the chance of symptom resolution. Especially in Asia, <jats:italic>H. pylori<\/jats:italic> should not be overlooked when considering the pathophysiology of FD. <jats:italic>H. pylori<\/jats:italic>\u2010associated dyspepsia might be dealt as a different disease entity from FD.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.06629.x","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T00:49:07Z","timestamp":1301359747000},"page":"42-45","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Can <i>Helicobacter pylori<\/i>\u2010associated dyspepsia be categorized as functional dyspepsia?"],"prefix":"10.1111","volume":"26","author":[{"given":"Hidekazu","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Nishizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Hibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-8-671"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90142-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.25"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1847-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92816-X"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.8.1060"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.00032.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.08.044"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/S1542-3565(03)00184-8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812243392601"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812243392602"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002096"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-5-200103060-00008"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910073411502"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02236-4"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.08724.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328317b89e"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01909.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.04039.x"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1746.2011.06629.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1746.2011.06629.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T18:01:51Z","timestamp":1694541711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1746.2011.06629.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,28]]},"references-count":19,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1111\/j.1440-1746.2011.06629.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1746.2011.06629.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,28]]},"assertion":[{"value":"2011-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}