{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:08:56Z","timestamp":1789722536750,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T00:00:00Z","timestamp":1301270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Functional Dyspepsia has been defined by Rome III as the presence of one or more chronic dyspepsia symptoms in the absence of any organic, systemic, or metabolic disease that is likely to explain the symptoms. Delayed gastric emptying, antral hypomotility and altered intestinal motility, decreased gastric accommodation, H.<jats:italic>pylori<\/jats:italic> infection, enhanced visceral sensitivity, abnormal duodenal sensitivity to acid, carbohydrate maldigestion and psychological factors have all been identified in subgroups of patients with functional dyspepsia.<\/jats:p><jats:p><jats:bold>Relationship between H.pylori, FD and post infectious FD:\u2002<\/jats:bold> The relationship between H. pylori infection and functional dyspepsia is controversial. H.<jats:italic>pylori<\/jats:italic> infection is present in a minority of patients with FD. Symptoms and abnormalities of function such as gastric emptying have not been consistently shown to be related to H.<jats:italic>pylori<\/jats:italic> infection. However, meta\u2010analysis has shown that H.<jats:italic>pylori<\/jats:italic> eradication therapy in FD results in a small but statistically significant effect in H.<jats:italic>pylori<\/jats:italic> positive FD (relative risk reduction 10%). Guidelines for Helicobacter <jats:italic>pylori<\/jats:italic> infection have therefore strongly recommended H.<jats:italic>pylori<\/jats:italic> eradication therapy in H.<jats:italic>pylori<\/jats:italic> positive FD patients. Post\u2010infectious dyspepsia has been described as a distinct clinical entity, based on a large retrospective study that showed a subset of dyspeptic patients who had a history suggestive of post\u2010infectious dyspepsia. In a prospective study, investigators in Spain have found that development of dyspepsia was increased fivefold at 1 year after acute Salmonella gastroenteritis. In post\u2010infectious FD patients, early satiety, weight loss, nausea, and vomiting are frequently reported together with a higher prevalence of impaired gastric accommodation. More recently, infectious FD has been found to be associated with persisting focal T\u2010cell aggregates, decreased CD4+ cells and increased macrophage counts in the duodenum for several moths after acute infection. This suggests impaired ability of the immune system to terminate the inflammatory response after acute insult.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In conclusion, H. pylori infections, as well as other gut infections, have been associated with a subset of FD patients. Treatment of underlying infections can potentially lead to improvement in this group of patients.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.06649.x","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T00:49:07Z","timestamp":1301359747000},"page":"39-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Functional dyspepsia, <i>H. pylori<\/i> and post infectious FD"],"prefix":"10.1111","volume":"26","author":[{"given":"Kwong Ming","family":"Fock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018833701109"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90004-I"},{"issue":"2","key":"e_1_2_7_5_2","article-title":"Eradication of helicobacter pylori for non\u2010ulcer dyspepsia","author":"Moayyedi P","year":"2008","journal-title":"Cochrane Database Syst. 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