{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:53:52Z","timestamp":1789736032447,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:00:00Z","timestamp":1308009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> The role of insulin resistance (IR) and hepatic steatosis in fibrogenesis in chronic hepatitis C infection (CHC) has yielded conflicting data and few studies have been performed in Asian\u2010region populations. We retrospectively investigated the relationship between host metabolic variables, including IR and hepatic steatosis, to hepatic fibrosis in Asian\u2010region CHC genotype 2\/3 patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 303 treatment\u2010na\u00efve Asian\u2010region patients with CHC genotype 2\/3 were enrolled in a multicenter phase 3 study of albinterferon alfa\u20102b plus ribavirin for 24\u2003weeks. IR was defined as Homeostasis Model for Assessment of IR (HOMA\u2010IR)\u2003&gt;\u20032. Baseline liver biopsy was evaluated by a single expert histopathologist. Post hoc subgroup logistic regression modeling selected for independent variables associated with significant fibrosis (METAVIR stage F2\u2010F4).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Insulin resistance was available in 263 non\u2010diabetic Asian\u2010region patients (hepatitis C virus\u20102 [HCV\u20102]\u2003=\u2003171, HCV\u20103\u2003=\u200392), and 433 non\u2010Asian region patients (407 \u201cCaucasian\u201d); METAVIR fibrosis prevalence F0\u2010F1 (minimal fibrosis)\u2003=\u2003201 (77%) and F2\u2010F4 (significant fibrosis)\u2003=\u200359 (23%), and steatosis prevalence of grade 0\u2003=\u2003169 (65%), grade 1\u2003=\u200364 (25%), grade 2\/3\u2003=\u200327 (10%). Median HOMA\u2010IR was 1.8 (interquartile range: 1.2\u20132.7); 100 (38%) patients had HOMA\u2010IR\u2003&gt;\u20032. Factors independently associated with significant fibrosis included HOMA\u2010IR (odds ratio [OR]\u2003=\u20038.42), necro\u2010inflammatory grade (OR\u2003=\u20033.17), age (OR\u2003=\u20031.07) and serum total cholesterol levels (OR\u2003=\u20030.008). This was similar to non\u2010Asian region patients, but steatosis was not associated with significant fibrosis in either cohort.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In this subgroup study of Asian\u2010region HCV genotype 2 or 3 patients, insulin resistance, along with age, cholesterol levels and necro\u2010inflammation, but not steatosis may be associated with significant hepatic fibrosis.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.06722.x","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T01:28:27Z","timestamp":1300325307000},"page":"1182-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Insulin resistance is independently associated with significant hepatic fibrosis in Asian chronic hepatitis C genotype 2 or 3 patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Keyur","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Long","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2010Mo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesananthan","family":"Shanmuganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satawat","family":"Thongsawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawesak","family":"Tanwandee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varocha","family":"Mahachai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutima","family":"Pramoolsinsap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mong","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hyup","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir R","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham R","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Pulkstenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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