{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:22:52Z","timestamp":1790839372940,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T00:00:00Z","timestamp":1314230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2011,9]]},"abstract":"Abstract<\/jats:title>Background and Aim:\u2002<\/jats:bold> jhp0562<\/jats:italic> and \u03b2\u2010(1,3)galT<\/jats:italic> (jhp0563<\/jats:italic>) of Helicobacter pylori<\/jats:italic> have been suggested as novel virulent factors; however, the clinical associations and functions of these genes remain unclear. We examined the prevalence of jhp0562<\/jats:italic>, \u03b2\u2010(1,3)galT<\/jats:italic>, and cagA<\/jats:italic> in the United States (US) and Japanese populations.<\/jats:p>Methods:\u2002<\/jats:bold> A total of 308 strains (171 from the US and 137 from Japan) were examined for the status of jhp0562<\/jats:italic>, \u03b2\u2010(1,3)galT<\/jats:italic>, and cagA<\/jats:italic> by polymerase chain reaction.<\/jats:p>Results:\u2002<\/jats:bold> There were significant differences in the status of jhp0562<\/jats:italic>, \u03b2\u2010(1,3)galT<\/jats:italic> and cagA<\/jats:italic> between the US and Japanese populations (P<\/jats:italic>\u2003<\u20030.001). In the US, the prevalence of \u03b2\u2010(1,3)galT<\/jats:italic> was significantly lower in strains isolated from patients with duodenal ulcer (DU) or gastric ulcer (GU) than those with gastritis (47.8% and 32.1% vs<\/jats:italic> 72.0%, P<\/jats:italic>\u2003<\u20030.01), and the absence of \u03b2\u2010(1,3)galT<\/jats:italic> was an independent factor discriminating DU and GU from gastritis (adjusted odds ratios, 4.21 and 8.52; 95% confidence intervals, 1.75 to 10.12 and 2.76 to 26.33, respectively). In the US, the prevalence of the jhp0562<\/jats:italic>\u2010positive\/\u03b2\u2010(1,3)galT<\/jats:italic>\u2010negative genotype was significantly higher in strains from DU and GU patients than in those from gastritis patients (50.0%, 67.9%, and 24.4%, P<\/jats:italic>\u2003<\u20030.01) and the cagA<\/jats:italic> status was significantly correlated with that of jhp0562<\/jats:italic> and inversely correlated with that of \u03b2\u2010(1,3)galT<\/jats:italic>. In contrast, the prevalence of these three genes was not significantly different in Japan.<\/jats:p>Conclusions:\u2002<\/jats:bold> jhp0562<\/jats:italic> or \u03b2\u2010(1,3)galT<\/jats:italic> can be used to discriminate peptic ulcers from gastritis in the US, but not in Japan.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.06779.x","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T12:04:24Z","timestamp":1305720264000},"page":"1451-1456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of two homologous genes encoding glycosyltransferases of Helicobacter pylori<\/i> in the United States and Japan"],"prefix":"10.1111","volume":"26","author":[{"given":"Miyuki","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Matsunari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Watada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Fujioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Yamaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70019-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.041"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34781"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00123-06"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/16495"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.63.3.675-707.1999"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00401-10"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.08.018"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1586\/egh.10.7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1998.08056.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268899003209"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01285.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10096-002-0865-3","article-title":"Helicobacter pylori virulence genotypes in Portuguese children and adults with gastroduodenal pathology","volume":"22","author":"Oleastro M","year":"2003","journal-title":"Eur. 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