{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:26:14Z","timestamp":1780392374392,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Metabolic syndrome has been associated with an increased risk for colorectal cancer. Non\u2010alcoholic fatty liver disease (NAFLD) is regarded as a hepatic manifestation of metabolic syndrome. We investigated whether NAFLD is associated with colorectal neoplasms in Korean women.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This retrospective cohort study included data from 5517 women, aged 35\u201380\u2003years, who underwent life insurance company health examinations between July 2002 and June 2006. Fatty liver disease was assessed by abdominal ultrasound, with NAFLD defined as fatty liver disease in the absence of alcohol use of &gt;\u200340\u2003g\/week or other secondary causes. The incidence of colorectal neoplasms through December 2008 was obtained through medical certificate codes for insurance claims. The association between NAFLD and the risk of colorectal neoplasms was estimated using standard Cox proportional hazards models.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the study population, 15.1% were diagnosed with NAFLD. During follow\u2010up, 65 women were verified as having adenomatous polyps and 15 as having colorectal cancer. Adjusted relative risks (95% confidence interval [CI]) for adenomatous polyps by age, low high\u2010density lipoprotein\u2010cholesterol, and NAFLD were 1.12 (95% CI 1.09\u20131.15), 2.56 (95% CI 1.53\u20134.28) and 1.94 (95% CI 1.11\u20133.40). Adjusted relative risks (95% CI) for colorectal cancer by age and NAFLD were 1.23 (95% CI 1.17\u20131.29) and 3.08 (95% CI 1.02\u20139.34).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our findings demonstrate a significant relationship between NAFLD and colorectal neoplasms. Among the various manifestations of metabolic syndrome, NAFLD may predict the development of colorectal neoplasms in Korean women.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.06816.x","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T18:48:37Z","timestamp":1308336517000},"page":"91-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Colorectal neoplasms in relation to non\u2010alcoholic fatty liver disease in Korean women: A retrospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"Young In","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Suk","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Soon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20006"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21690"},{"key":"e_1_2_5_4_2","unstructured":"Korea National Statistical Office.2008 Report of Statistics in Mortality in Korean.2009."},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02120.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21950"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1158\/1055-9965.133.14.1","article-title":"Diabetes mellitus and subsite\u2010specific colorectal cancer risks in the Iowa Women's Health Study","volume":"14","author":"Limburg PJ","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.9.847"},{"key":"e_1_2_5_9_2","first-page":"339","article-title":"Risk of malignancies in patients with insulin\u2010treated diabetes mellitus: results of a population\u2010based trial with 10\u2010year follow\u2010up (JEVIN)","volume":"10","author":"Schiel R","year":"2005","journal-title":"Eur. J. Med. Res."},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0199"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.216"},{"key":"e_1_2_5_12_2","first-page":"385","article-title":"Colorectal cancer mortality and factors related to the insulin resistance syndrome","volume":"11","author":"Colangelo LA","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.3.836S"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.11.3109S"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(08)74597-X"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1024"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-10-200511150-00009"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1844"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36569"},{"issue":"1","key":"e_1_2_5_20_2","first-page":"s5","article-title":"The epidemiology of nonalcoholic fatty liver disease in adults","volume":"40","author":"Clark JM","year":"2006","journal-title":"J. Clin. Gastroenterol."},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.09.009"},{"key":"e_1_2_5_22_2","first-page":"26","article-title":"Prevalence and associated factors of nonalcoholic fatty liver disease in the health screen examinees","volume":"70","author":"Seo SH","year":"2006","journal-title":"Korean J. Med."},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03586.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01646.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0096(199601)24:1<25::AID-JCU4>3.0.CO;2-N"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.03.021"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200304000-00015"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06117.x"},{"key":"e_1_2_5_29_2","first-page":"485","article-title":"The metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self\u2010Defense Forces health study","volume":"6","author":"Morita T","year":"2005","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.11.005"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0239"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-2-200001180-00004"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.27.142"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-1-200207020-00006"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.02.014"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200005000-00006"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35354"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1746.2011.06816.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1746.2011.06816.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:56:09Z","timestamp":1697345769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1746.2011.06816.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,21]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1440-1746.2011.06816.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1746.2011.06816.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,21]]},"assertion":[{"value":"2011-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}