{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:41:38Z","timestamp":1773268898503,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T00:00:00Z","timestamp":1327017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> We intended to determine whether laparoscopic splenectomy (Lap\u2010Sp) contributes to treatment with interferon therapy in hepatitis C virus (HCV)\u2010cirrhotic patients with thrombocytopenia caused by hypersplenism.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> From December 2004 to August 2008, 100 cirrhotic patients (54 men and 46 women) underwent Lap\u2010Sp for a clinical application of interferon therapy. All the patients were Child\u2013Pugh class A or B with thrombocytopenia (average platelet count, 56\u2003\u00d7\u200310<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>). The HCV genotype was type 1 in 80 patients and type 2 in 20 patients.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Pure laparoscopic or hand\u2010assisted laparoscopy was performed in 78 and 22 patients, respectively, without mortality. Conversion to open surgery was not required in any of the patients. The platelet counts improved (mean platelet count 172\u2003\u00d7\u200310<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup> 1\u2003month after surgery) and interferon (IFN) therapy was started in 97 patients. In this study period, 36 patients obtained a sustained virologic response. Eight patients discontinued IFN therapy because of depression, neutropenia or other reasons.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Lap\u2010Sp permits most patients with HCV cirrhosis and hypersplenism to receive sufficient IFN therapy. Therefore, Lap\u2010Sp can become a strong supportive surgery for cirrhotic patients who require antiviral therapy.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.06870.x","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T04:06:29Z","timestamp":1311825989000},"page":"286-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Laparoscopic splenectomy with interferon therapy in 100 hepatitis\u2010C\u2010virus\u2010cirrhotic patients with hypersplenism and thrombocytopenia"],"prefix":"10.1111","volume":"27","author":[{"given":"Tomohiko","family":"Akahoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morimasa","family":"Tomikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Kawanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Furusyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Kinjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-3-199908030-00003"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21492"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290439"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00394-9"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.266.6.849"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36502"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(94)90109-0"},{"key":"e_1_2_5_9_2","first-page":"847","article-title":"Laparoscopic splenectomy for portal hypertension","volume":"49","author":"Hashizume M","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-009-0149-8"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2003.10.009"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-009-0653-6"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190629"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05319.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200609000-00015"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806104"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.009"},{"key":"e_1_2_5_19_2","first-page":"1022","article-title":"Splenectomy enhances liver regeneration through tumor necrosis factor (TNF)\u2010alpha following dimethylnitrosamine\u2010induced cirrhotic rat model","volume":"48","author":"Murata K","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02667.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807650"},{"key":"e_1_2_5_22_2","first-page":"411","article-title":"Case of overwhelming postsplenectomy infection (OPSI) with chronic hepatitis type C during peginterferon\/ribavirin combination therapy","volume":"106","author":"Okamura S","year":"2009","journal-title":"Nippon. 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