{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T16:30:16Z","timestamp":1777134616827,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T00:00:00Z","timestamp":1332374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> The aim of this study was to explore the distribution and clinical characteristics of four subtypes of irritable bowel syndrome (IBS) based on Rome III criteria in Chinese.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 754 consecutive IBS outpatients from three tertiary hospitals in China were included. Diagnostic criteria were based on Rome II or Rome III.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Among 754 outpatients, 510 (67.6%) patients met the Rome II criteria, 735 (97.5%) patients met the Rome III criteria and 492 (65.3%) patients met both sets of criteria. Among 735 patients who met the Rome III criteria, 66.3% had IBS with diarrhea (IBS\u2010D), 14.7% had IBS with constipation (IBS\u2010C), 4.2% had mixed IBS (IBS\u2010M) and 14.8% had unsubtyped IBS (IBS\u2010U). Most of the IBS\u2010D, IBS\u2010C and IBS\u2010M patients based on the Rome III criteria matched the diarrhea\u2010predominant IBS, constipation\u2010predominant IBS and alternating IBS based on the Rome II criteria, respectively. Among IBS\u2010U patients, 57.0%, 33.3% and 9.7% had constipation\u2010predominant IBS, diarrhea\u2010predominant IBS and alternating IBS, respectively. For IBS\u2010M, the frequencies of bowel movements were stable in 48.4% patients and variable in 51.6% patients. Defecation urgency and straining were most frequent in IBS\u2010M and least frequent in IBS\u2010U patients than other subtypes. About 77.2% of IBS\u2010U patients had abnormal stool frequency (&lt;\u20033 times\/week or &gt;\u20033 times\/day).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The Rome III criteria are more sensitive and practical in diagnosing IBS. IBS\u2010D is the most frequent subtype, which is followed by IBS\u2010U, IBS\u2010C and IBS\u2010M. IBS\u2010U is a new subtype, which warrants further studies.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.06930.x","type":"journal-article","created":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T19:57:14Z","timestamp":1316462234000},"page":"760-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Subtypes of irritable bowel syndrome on Rome III criteria: A multicenter study"],"prefix":"10.1111","volume":"27","author":[{"given":"Xin","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Sheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Hong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Bing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Hua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31815bd749"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03422.x"},{"key":"e_1_2_6_4_2","first-page":"669","volume-title":"Rome II: The Functional Gastrointestinal Disorders","author":"Drossman DA","year":"2000"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2006.03.008","volume-title":"Rome III. 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