{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:46:39Z","timestamp":1722930399569},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> We aimed to determine whether reflux\u2010 and symptom\u2010related parameters can predict the efficacy of proton pump inhibitors (PPI) in non\u2010erosive reflux disease (NERD).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty\u2010seven NERD patients who had experienced heartburn more than once a week within the previous month were enrolled. Intraesophageal pH before therapy was measured simultaneously at 5 and 15\u2003cm above the esophagogastric junction (EGJ) for 24\u2003h. The PPI rabeprazole was administered at a dose of 10\u2003mg once daily for 4\u2003weeks. In the event that heartburn was not relieved, the dose was increased to 10\u2003mg twice daily for an additional 2\u2003weeks, and again to 20\u2003mg twice daily for another 2\u2003weeks.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Univariate analysis demonstrated no significant associations between any reflux\u2010 or symptom\u2010related parameters at either site and complete heartburn relief after 4\u2003weeks, or cumulative complete heartburn relief after 8\u2003weeks. However, post\u2010hoc analysis demonstrated more satisfactory heartburn relief after 4\u2003weeks in patients with a high symptom index compared with those with a low symptom index, at 5\u2003cm above the EGJ (<jats:italic>P<\/jats:italic>\u2003=\u20030.009). Cumulative satisfactory heartburn relief after 8\u2003weeks was also greater in patients with a high total number of acid reflux episodes compared with those with a low total number of episodes, at 15\u2003cm above the EGJ (<jats:italic>P<\/jats:italic>\u2003=\u20030.037).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Pre\u2010therapeutic pH monitoring in the lower and mid\u2010esophagus is useful for predicting the efficacy of PPI in NERD patients.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.06975.x","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T18:57:38Z","timestamp":1321642658000},"page":"899-906","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Predicting the efficacy of proton pump inhibitors in patients with non\u2010erosive reflux disease before therapy using dual\u2010channel 24\u2010h esophageal pH monitoring"],"prefix":"10.1111","volume":"27","author":[{"given":"Tomohiko","family":"Shimatani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsushige","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoichi","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Kurosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Mannen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Hongo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Acid\u2010Related Symptom Research (ARS) Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018822532736"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01181.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05769.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03350.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(03)00011-X"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24840"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.074690"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01990.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666001-00003"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.1101982"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02801.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2760-0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.09.012"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03190.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01207.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02162.x"},{"issue":"2","key":"e_1_2_7_18_2","first-page":"A128","article-title":"Intraesophageal pH monitoring cannot predict the efficacy of PPI in patients with NERD: a Japanese multicenter prospective study by the Acid\u2010Related Symptoms Research Group","volume":"25","author":"Shimatani T","year":"2010","journal-title":"J. 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