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However, since liver cirrhosis is highly oncogenic, evaluation of the effects of ABM<jats:italic>i<\/jats:italic> on the mechanisms of hepatocarcinogenesis is of great importance. Therefore, frequent ABM<jats:italic>i<\/jats:italic> was performed in hepatocarcinogenic mice, and its effects on hepatocarcinogenesis were analyzed. The <jats:italic>N<\/jats:italic>\u2010nitrosodiethylamine (DEN)\/green fluorescent protein (GFP)\u2010carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) model was developed by administering DEN once, followed by repeated administration of CCl<jats:sub>4<\/jats:sub> intraperitoneally as for the control group. In the administration (ABM<jats:italic>i<\/jats:italic>) group, GFP\u2010positive bone marrow cells were infused through a tail vein. The kinetics of hepatocarcinogenesis were evaluated histologically 4.5\u2003months after DEN treatment. At 4.5\u2003months, there was significantly lower incidence of foci and tumors in the ABM<jats:italic>i<\/jats:italic> group, and they were smaller in number, while their size was almost equal. No GFP\u2010positive tumors were found in ABM<jats:italic>i<\/jats:italic> livers. Moreover, ABM<jats:italic>i<\/jats:italic> livers showed significantly reduced liver fibrosis, consistent with significantly lower 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine levels, higher superoxide dismutase activity, and increased nuclear translocation of nuclear factor\u2010erythroid 2 p45\u2010related factor 2. These results demonstrate that frequent ABM<jats:italic>i<\/jats:italic> might contribute to suppressed tumor initiation during stages of hepatocarcinogenesis, consistent with improvements in liver fibrosis and stabilization of redox homeostasis.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.07016.x","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T16:17:21Z","timestamp":1328804241000},"page":"104-111","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Autologous bone marrow cell infusions suppress tumor initiation in hepatocarcinogenic mice with liver 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