{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:38:14Z","timestamp":1783535894170,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T00:00:00Z","timestamp":1332374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Refractory ascites in liver\u2010cirrhosis is associated with a poor prognosis. We performed a prospective study to investigate whether aggressive nutritional\u2010support could improve outcomes in cirrhotic patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Cirrhotic patients undergoing serial large\u2010volume paracentesis for refractory\u2010ascites were enrolled and randomized into three groups. Group A received post\u2010paracentesis intravenous nutritional\u2010support in addition to a balanced oral diet and a late\u2010evening protein snack, group B received the same oral nutritional\u2010protocol as the first group but without parenteral support, and group C (the control group) received a low\u2010sodium or sodium\u2010free diet. Clinical, anthropometric and laboratory nutritional parameters and biochemical tests of liver and renal function were reported for 12 months of follow\u2010up.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We enrolled 120 patients, who were randomized into three groups of equal size. Patients on the nutritional\u2010protocol showed better preservation of clinical, anthropometric and laboratory nutritional parameters that were associated with decreased deterioration of liver function compared with patients on the low\u2010sodium or sodium\u2010free diet (group C). Groups A and B had lower morbidity and mortality rates than the control group (C). Mortality rates were significantly better in patients who were treated with parenteral\u2010nutritional\u2010support than for the other two groups. In patients who were on the nutritional\u2010protocol, there was a reduction in the requirement of taps for the treatment of refractory ascites.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Post\u2010paracentesis parenteral\u2010nutritional\u2010support with a balanced oral diet and an evening protein snack appears to be the best care protocol for patients with liver\u2010cirrhosis that has been complicated by refractory\u2010ascites.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.07043.x","type":"journal-article","created":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T11:46:54Z","timestamp":1323172014000},"page":"813-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Preservation of nutritional\u2010status in patients with refractory ascites due to hepatic cirrhosis who are undergoing repeated paracentesis"],"prefix":"10.1111","volume":"27","author":[{"given":"Paolo","family":"Sorrentino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Castaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Tarantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bracigliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Perrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oreste","family":"Perrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaela","family":"Vecchione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"D' Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(90)90231-P"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(99)00187-2"},{"key":"e_1_2_5_4_2","first-page":"118","article-title":"Malabsorption and nutritional abnormalities in patients with liver\u2010cirrhosis","volume":"22","author":"Romiti A","year":"1990","journal-title":"Ital. 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