{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:57:27Z","timestamp":1790776647283,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Postinfectious irritable bowel syndrome (PI\u2010IBS), which results from inflammation has been emphasized a lot recently. Dendritic cells (DCs) may contribute to intestinal mucosal immune activation in the pathogenesis of PI\u2010IBS. This study tested the hypothesis that phenotype and function of intestinal lamina propria DCs (LPDCs) changed in the development of a PI\u2010IBS mouse model.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Mice infected with <jats:italic>Trichinella\u2003spiralis<\/jats:italic> underwent abdominal withdrawal reflex (AWR) to evaluate visceral sensitivity. LPDCs were isolated and purified by intestine digestion and magnetic label\u2010based technique. Surface markers were analyzed by flow cytometry. Endocytic activity, mixed lymphocyte reaction (MLR) and chemotaxis were studied. Cytokine production of the LPDCs cocultured with CD4<jats:sup>+<\/jats:sup> T cells was determined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Intestinal inflammation resolved after 8\u2003weeks infection with sustained visceral hyperalgesia. Surface markers CD86 and MHCII were lower in the acute infection group, but increased in the PI\u2010IBS stage. Enhanced ability of endocytic activity and decreased abilities to attract and stimulate CD4<jats:sup>+<\/jats:sup> T cell proliferation were in the acute infection group. However, LPDCs in the PI\u2010IBS stage showed weakened endocytic ability with enhanced abilities to attract and stimulate CD4<jats:sup>+<\/jats:sup> T cell proliferation. Cocultured LPDCs with CD4<jats:sup>+<\/jats:sup> T cells showed a predominant Th2 response in the acute infection stage, and more important roles of Th1, Th17 responses in the PI\u2010IBS stage.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The hypothesis was supported that the phenotype and function of LPDCs changed in the development of PI\u2010IBS, which induced the maintenance of intestinal mucosal immune activation and might provide a clue for the treatment of the disease.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2011.07046.x","type":"journal-article","created":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T11:47:01Z","timestamp":1323172021000},"page":"935-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Characteristics of intestinal lamina propria dendritic cells in a mouse model of postinfectious irritable bowel syndrome"],"prefix":"10.1111","volume":"27","author":[{"given":"Yanqin","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangcheng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000156403.37240.30"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117548"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.02.020"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.6.743"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.021154"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37059"},{"key":"e_1_2_6_9_2","first-page":"307","article-title":"The irritable colon syndrome a study of the clinical features, predisposing causes, and prognosis in 130 cases","volume":"31","author":"Chaudhary N","year":"1962","journal-title":"Q. 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