{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:25:54Z","timestamp":1763641554437},"reference-count":18,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T00:00:00Z","timestamp":1333497600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 2008, a 44\u2010year\u2010old woman with mild epigastralgia diagnosed as having <jats:italic>Helicobacter pylori<\/jats:italic>\u2010positive chronic gastritis without peptic ulcer underwent eradication therapy with lansoprazole (LPZ), amoxicillin (AMPC) and clarithromycin (CAM) for 7\u2003days, but it failed, so treatment with rabeprazole, AMPC, and metronidazole (MNZ) for another 7\u2003days was given, but it also failed. She was then prescribed a modified, 14\u2010day sequential therapy of LPZ and AMPC with an increased dose of CAM followed by MNZ supplement, but the infection was still not eradicated. The <jats:italic>H.\u2003pylori<\/jats:italic> was cultured and examined for antibiotic susceptibility with the agar dilution method and was found to be resistant to CAM, MNZ, and levofloxacin, and non\u2010sensitive to AMPC, namely multiple\u2010antibiotic\u2010resistant, although sensitive to minocycline. The CYP2C19 genotype of the patient was an extensive metabolizer (G681A: G\/A, G636A: G\/G). In 2010, she gave informed consent for a 14\u2010day, tailor\u2010made, modified classical (or modified high\u2010dose PPI\u2003+\u2003AMPC) quadruple therapy comprising 30\u2003mg LPZ, 500\u2003mg AMPC and 500\u2003mg bismuth subnitrate, qid, and 100\u2003mg minocycline, bid. Two months later, her urea breath test was negative. Histology and bacterial culture were still negative 1\u2003year after the therapy. She did not have any adverse events during or after the novel therapy, nor did she feel any further epigastralgia.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2012.07069.x","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T15:21:09Z","timestamp":1333552869000},"page":"108-111","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Multiple\u2010antibiotic\u2010resistant <i>Helicobacter pylori<\/i> infection eradicated with a tailor\u2010made quadruple therapy"],"prefix":"10.1111","volume":"27","author":[{"given":"Shigemi","family":"Nakajima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayuki","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Maruoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612003399013"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00738.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(99)70017-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.1996.tb00003.x"},{"key":"e_1_2_6_6_2","first-page":"561","article-title":"Report of the committee on the antibiotics\u2010susceptibility test in Helicobacter pylori eradication therapy","volume":"48","author":"Nasu M","year":"2000","journal-title":"Jpn. 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