{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:29:59Z","timestamp":1769498999852,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T00:00:00Z","timestamp":1345507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Unexplained liver injury including fibrosis and portal hypertension has rarely been reported among patients with HIV in the absence of co\u2010infection with hepatitis B (HBV) or hepatitis C (HCV). We describe a series of HIV mono\u2010infected patients with evidence of non\u2010cirrhotic portal hypertension.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> HIV\u2010infected patients with evidence of portal hypertension who were anti\u2010HBV and anti\u2010HCV negative and HBV and HCV RNA polymerase chain reaction (PCR) negative were identified from patients managed by the Victorian statewide HIV referral service located at The Alfred Hospital, Melbourne. Portal hypertension was defined as either radiological or endoscopic evidence of varices, portal vein flow obstruction, or elevated hepatic venous pressure gradient (HPVG).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Five patients were found to have portal hypertension. These patients were male, aged 41 to 65\u2003years, with known duration of HIV infection between 11 to 25\u2003years. All had been treated with antiretroviral therapy, including didanosine. Tests for metabolic, autoimmune, and hereditary causes of liver disease failed to establish an etiology for the liver injury. All had radiological or endoscopic findings of varices, and four patients had radiological features of portal vein obstruction or flow reversal. Only one patient underwent HPVG measurement, which was elevated. Non\u2010invasive fibrosis assessment revealed increased liver stiffness in three (out of four) patients, and no cirrhotic features were found on those who underwent liver biopsy.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> To our knowledge, this is the largest published series of non\u2010cirrhotic portal hypertension in HIV mono\u2010infected patients in Australia. Further research is needed to understand what relationship, if any, HIV or its treatments might have on liver injury over time.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2012.07148.x","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T09:54:53Z","timestamp":1334310893000},"page":"1512-1519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Non\u2010cirrhotic portal hypertension in HIV mono\u2010infected patients"],"prefix":"10.1111","volume":"27","author":[{"given":"Belinda D","family":"Jackson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph S","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer F","family":"Hoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart K","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Colman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret E","family":"Hellard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J","family":"Sasadeusz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Iser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22665"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.034"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01088.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/521857"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.165"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/135965350801300111"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181bb27b1"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283389e26"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3280fa81cb"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-6"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00712.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31757-0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.04.023"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1310\/hct0906-440"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21493"},{"key":"e_1_2_7_17_2","first-page":"359","article-title":"Obliterative portal venopathy of the liver. 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