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The timing of appearance of this dysfunction, however, is unclear.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Lean and obese subjects from three different age groups were studied noninvasively: 50 newborns (1\u201312\u2003months old, six obese), 18 pre\u2010adolescents (7\u20138\u2003years old, seven obese), and 99 adults (22\u201380\u2003years old, 32 obese) classified according to standard normal tables and body mass index. Changes of fasting\/postprandial gallbladder and gastric motility were assessed simultaneously by functional ultrasonography in response to milk (newborns and pre\u2010adolescents) and to a liquid test meal (adults).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In newborns, fasting and postprandial gallbladder volumes and gastric emptying were similar between obese and lean subjects. In pre\u2010adolescents, obese subjects had a larger fasting gallbladder volume, with slower postprandial gastric emptying than lean subjects. In obese adults, the most evident dysfunction emerged, with larger fasting and postprandial residual gallbladder volume, and slower postprandial gastric emptying than lean subjects.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Obese subjects display abnormal gallbladder and gastric motility patterns, which first appear in pre\u2010adolescents and deteriorate in adults. Such abnormalities are absent in obese newborns. Functional ultrasonography can detect altered cholecysto\u2010gastric motility at the earliest stage. Our findings suggest an age\u2010related decline of motility, probably secondary to excessive fat and insulin\u2010resistance.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2012.07149.x","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T09:55:18Z","timestamp":1334310918000},"page":"1298-1305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Gallbladder and gastric motility in obese newborns, pre\u2010adolescents and adults"],"prefix":"10.1111","volume":"27","author":[{"given":"Agostino","family":"Di Ciaula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Q\u2010H","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i11.1653"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-9-88"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802421"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1728"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.22.2845"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000187816.31213.06"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2004.04.010"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22204"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(01)00046-4"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1995.tb01953.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.10191"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005497517854"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-8902.2004.0344.x"},{"key":"e_1_2_6_15_2","first-page":"1378","article-title":"Gallstone prevalence and gallbladder volume in children and adolescents: an epidemiological ultrasonographic survey and relationship to body mass index","volume":"84","author":"Palasciano G","year":"1989","journal-title":"Am. 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