{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:06:09Z","timestamp":1791518769631,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T00:00:00Z","timestamp":1345507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aim:\u2002<\/jats:bold> Symptoms of functional dyspepsia (FD) are highly prevalent in patients with irritable bowel syndrome (IBS). However, the effects of therapeutic agents for IBS on the pathophysiology of FD are unclear. In this study, therefore, we examined the effects of ramosetron, a serotonin 5\u2010HT<jats:sub>3<\/jats:sub> receptor antagonist, on corticotropin releasing factor (CRF)\u2010 and soybean oil\u2010induced delays in gastric emptying of rats, in comparison with anti\u2010diarrheal agent and spasmolytics. The involvement of 5\u2010HT and the 5\u2010HT<jats:sub>3<\/jats:sub> receptor in delayed gastric emptying was also evaluated.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Corticotropin releasing factor was administered intravenously to rats 10\u2003min before oral administration of 0.05% phenol red solution, and the amount remaining in the stomach was measured after 30\u2003min. Soybean oil was administered orally with glass beads, and the number of residual beads in the stomach was counted 1\u2003h later.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Both CRF and soybean oil inhibited gastric emptying dose\u2010dependently. Ramosetron and itopride, a gastro\u2010prokinetic agent, significantly reduced both CRF\u2010 and soybean oil\u2010induced delays in gastric emptying, while an anti\u2010diarrheal agent and spasmolytics aggravated them. Pretreatment with <jats:italic>p<\/jats:italic>\u2010chlorophenylalanine for 2\u2003days to reduced the synthesis of endogenous 5\u2010HT diminished the effects of both CRF and soybean oil on gastric emptying. A 5\u2010HT<jats:sub>3<\/jats:sub> receptor agonist <jats:italic>m<\/jats:italic>\u2010chlorophenylbiguanide suppressed gastric emptying of both phenol red and glass beads, and those effects were reversed by ramosetron.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results suggest that CRF and soybean oil suppress gastric emptying in rats by activating 5\u2010HT<jats:sub>3<\/jats:sub> receptors, and that by antagonizing these receptors, ramosetron may ameliorate symptoms of FD in clinical settings.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2012.07172.x","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T16:17:31Z","timestamp":1336061851000},"page":"1505-1511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Inhibitory effect of ramosetron on corticotropin releasing factor\u2010 and soybean oil\u2010induced delays in gastric emptying in rats"],"prefix":"10.1111","volume":"27","author":[{"given":"Takuya","family":"Hirata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Keto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Yamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Sengoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i17.2701"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.suppl_1.i50"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"issue":"1","key":"e_1_2_5_6_2","first-page":"S1","article-title":"An evidence\u2010based position statement on the management of irritable bowel syndrome","volume":"104","author":"Brandt LJ","year":"2009","journal-title":"Am. 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