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The ultimate goal of pharmacogenetic research is to find robust genetic predictors of drug response that enable the development of prospective genetic tests to reliably identify patients at risk of non\u2010response or of developing an adverse effect prior to the drug being prescribed. Currently, thiopurine S\u2010methyltransferase (TPMT) deficiency is the only pharmacogenetic factor that is prospectively assessed before azathioprine or 6\u2010mercaptopurine immunomodulation is commenced in patients with Crohn's disease (CD). As yet no other inherited determinant of drug response has made the transition from bench to bedside for the management of this disease. In this review we summarize what is known about TPMT deficiency and explore whether there is evidence to support a role of other genetic polymorphisms in predicting the response of CD patients to thiopurine drugs, methotrexate, and anti\u2010tumor necrosis factor \u03b1 (TNF\u03b1) therapy.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2012.07220.x","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T13:09:15Z","timestamp":1340888955000},"page":"1546-1554","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Current relevance of pharmacogenetics in immunomodulation treatment for Crohn's disease"],"prefix":"10.1111","volume":"27","author":[{"given":"Rebecca L","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray L","family":"Barclay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70354-4"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.10.147"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01690.x"},{"key":"e_1_2_7_5_2","first-page":"651","article-title":"Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity","volume":"32","author":"Weinshilboum RM","year":"1980","journal-title":"Am. 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