{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:17:55Z","timestamp":1792815475726,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T00:00:00Z","timestamp":1348012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The cardiac changes in acute pancreatitis have been earlier studied but the data on their prognostic significance is limited. This study was done to determine electrocardiographic (<jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>) and echocardiographic changes in acute pancreatitis and determine their prognostic significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010two consecutive patients (mean age 36.5\u2009\u00b1\u200911\u2009years (44 males)) with acute pancreatitis and without prior cardiovascular comorbidites were prospectively enrolled and subjected to clinical, laboratory and radiological investigation. <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> and echocardiography was done at admission and during follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen patients (32.7%) had mild pancreatitis and 35 (67.3%) patients had severe pancreatitis. Sinus tachycardia was the most common <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> abnormality. <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> prolongation was seen in 30\/52 (57.7%) patients. On echocardiography, no patient had systolic dysfunction but 31\/52 (59.6%) patients had diastolic dysfunction. All 22 patients with <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> interval &lt;\u2009440\u2009ms survived compared with 8\/30 patients with <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> interval \u2265\u2009440\u2009ms who died (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). All eight patients who died had evidence of diastolic dysfunction (100%). None of the patients without diastolic dysfunction succumbed to illness (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Pericardial effusion was present in 6\/52 (11.5%) patients. Of the eight patients who died, pericardial effusion was present in three (37.5%) patients and this frequency was significantly higher than that in patients who recovered (3\/44 [6.8%]; <jats:italic>P<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Electrocardiographic and echocardiographic changes are seen in more than 50% of patients with acute pancreatitis. Prolonged <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> interval, pericardial effusion and diastolic dysfunction are associated with higher mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1440-1746.2012.07229.x","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T15:38:27Z","timestamp":1343749107000},"page":"1576-1580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Diastolic dysfunction, prolonged <scp>QTc<\/scp> interval and pericardial effusion as predictors of mortality in acute pancreatitis"],"prefix":"10.1111","volume":"27","author":[{"given":"Nikhil","family":"Nadkarni","sequence":"first","affiliation":[{"name":"Departments of Gastroenterology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak Kumar","family":"Bhasin","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surinder Singh","family":"Rana","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Bahl","sequence":"additional","affiliation":[{"name":"Cardiology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj Kant","family":"Sinha","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chalapathi","family":"Rao","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewal Kishan","family":"Talwar","sequence":"additional","affiliation":[{"name":"Cardiology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00856.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2008.04.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1993.01420170122019"},{"key":"e_1_2_5_5_1","first-page":"69","article-title":"Prognostic signs and the role of operative management in acute pancreatitis","volume":"139","author":"Ranson JHC","year":"1974","journal-title":"Surg. 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