{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:24:21Z","timestamp":1793305461902,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Gastrointestinal (GI<\/jats:styled-content>) luminal obstruction or malignant biliary obstruction (MBO<\/jats:styled-content>) is not a rare condition in gastric cancer patients with peritoneal metastasis. The role of endoscopic or percutaneous interventions is not fully elucidated in this setting.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 123 patients with unresectable or recurrent gastric adenocarcinoma with peritoneal metastasis receiving intravenous and intraperitoneal paclitaxel combined with S<\/jats:styled-content>\u20101 were retrospectively studied. Safety and efficacy of interventions for GI<\/jats:styled-content> luminal obstruction and MBO<\/jats:styled-content> were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 27 patients (22%) underwent GI<\/jats:styled-content> luminal and\/or biliary interventions; GI<\/jats:styled-content> luminal alone in 10, biliary alone in 10 and both in seven, with a technical success rate of 100%. Clinical success rate was 65% in self\u2010expandable metallic stents (SEMS<\/jats:styled-content>) placement for GI<\/jats:styled-content> luminal obstruction. E<\/jats:styled-content>astern C<\/jats:styled-content>ooperative O<\/jats:styled-content>ncology G<\/jats:styled-content>roup (ECOG<\/jats:styled-content>) performance status (PS<\/jats:styled-content>) was prognostic of clinical success in GI<\/jats:styled-content> luminal stenting (100% in PS<\/jats:styled-content> of 1 vs<\/jats:italic> 14% in PS<\/jats:styled-content> of 2\u20133, P<\/jats:italic>\u2009<\u20090.001). Biliary drainage (endoscopic SEMS<\/jats:styled-content> placement in four and percutaneous transhepatic biliary drainage in 12) relieved obstructive jaundice in 94%. Six complications were observed: four after GI<\/jats:styled-content> luminal stenting (two occlusion and one aspiration pneumonia) and two after biliary stenting (one cholangitis and one cholecystitis). Median survival after the initial intervention was 5.7\u2009months. PS<\/jats:styled-content> at interventions was prognostic of survival after interventions (12.3\u2009months in PS<\/jats:styled-content> of 1 vs<\/jats:italic> 2.2\u2009months in PS<\/jats:styled-content> of 2 or 3, P<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Endoscopic or percutaneous interventions for GI<\/jats:styled-content> luminal obstruction or MBO<\/jats:styled-content> were feasible and effective in gastric cancer patients with peritoneal dissemination receiving combination chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1440-1746.2012.07241.x","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T16:54:15Z","timestamp":1343753655000},"page":"1796-1800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of intervention for biliary and gastric\/intestinal obstruction in gastric cancer with peritoneal 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