{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:01:44Z","timestamp":1791352904199,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Lactase non\u2010persistence is common in I<\/jats:styled-content>ndia. We evaluated: (i) frequency of lactase gene (C<\/jats:styled-content>\/T<\/jats:styled-content>\u201013910 and G<\/jats:styled-content>\/A<\/jats:styled-content>\u201022018) polymorphisms in irritable bowel syndrome (IBS<\/jats:styled-content>) and healthy controls (HC<\/jats:styled-content>), (ii) association between these polymorphisms and IBS<\/jats:styled-content>\u2010subtypes and symptoms.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 150 IBS<\/jats:styled-content> patients (R<\/jats:styled-content>ome\u2010III<\/jats:styled-content> criteria) and 252 age and gender\u2010matched HC<\/jats:styled-content> were evaluated for C<\/jats:styled-content>\/T<\/jats:styled-content>\u201013910 and G<\/jats:styled-content>\/A<\/jats:styled-content>\u201022018 genotypes using polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Totals of 79 (52%), 52 (35%) and 19 (13%) patients had diarrhea\u2010predominant IBS (D<\/jats:styled-content>\u2010IBS)<\/jats:styled-content>, constipation predominant IBS (C<\/jats:styled-content>\u2010IBS<\/jats:styled-content>) and alternating diarrhea and constipation IBS (A<\/jats:styled-content>\u2010IBS<\/jats:styled-content>), respectively (R<\/jats:styled-content>ome\u2010III<\/jats:styled-content>). Frequency of C<\/jats:styled-content>\/T<\/jats:styled-content>\u201013910 [genotypes: CC<\/jats:styled-content> 102 (68%), CT<\/jats:styled-content> 43 (29%), TT<\/jats:styled-content> 5 (3%) vs<\/jats:italic> CC<\/jats:styled-content> 155 (61%), CT<\/jats:styled-content> 83 (33%), TT<\/jats:styled-content> 14 (6%), P<\/jats:italic>\u2009>\u20090.05] and G<\/jats:styled-content>\/A<\/jats:styled-content>\u201022018 [GG<\/jats:styled-content> 97 (65%), GA<\/jats:styled-content> 41 (27%), AA<\/jats:styled-content> 12 (8%) vs<\/jats:italic> GG<\/jats:styled-content> 154 (61%), GA<\/jats:styled-content> 78 (31%), AA<\/jats:styled-content> 20 (8%), P<\/jats:italic>\u2009>\u20090.05] were similar among IBS<\/jats:styled-content> and HC<\/jats:styled-content>. Patients with D<\/jats:styled-content>\u2010IBS<\/jats:styled-content> more often had C<\/jats:styled-content>\/T<\/jats:styled-content>\u201013910 and G<\/jats:styled-content>\/A<\/jats:styled-content>\u201022018 genotypes than C<\/jats:styled-content>\u2010IBS<\/jats:styled-content> (CC<\/jats:styled-content> 71 [90%], CT<\/jats:styled-content> 6 [8%], TT<\/jats:styled-content> 2 [2%]) versus (24 [46%], 25 [48%], 3 [6%]), A<\/jats:styled-content>\u2010IBS<\/jats:styled-content> (7 [39%], 12 [63%], 0, [0%]) and HC<\/jats:styled-content> (155 [61%], 83 [33%], 14 [6%]), P<\/jats:italic>\u2009<\u20090.0001 and (GG<\/jats:styled-content> 69 [87%], GA<\/jats:styled-content> 6 [8%], AA<\/jats:styled-content> 4 [5%]) vs<\/jats:italic> (22 [42%], 24 [46%], 6 [12%]) vs<\/jats:italic> (6 [32%], 11 [58%], 2 [10%]), P<\/jats:italic>\u2009<\u20090.0001. IBS<\/jats:styled-content> with CC<\/jats:styled-content> and GG<\/jats:styled-content> genotypes more often had abdominal pain (P<\/jats:italic>\u2009=\u20090.005), distension (P<\/jats:italic>\u2009=\u20090.031) and higher stool frequency (P<\/jats:italic>\u2009=\u20090.003) and reported symptoms following dairy products than non\u2010CC<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.0001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Though C<\/jats:styled-content>\/T<\/jats:styled-content>\u201013910 and G<\/jats:styled-content>\/A<\/jats:styled-content>\u201022018 polymorphisms were comparable among IBS<\/jats:styled-content> and HC<\/jats:styled-content>, these were more common among D<\/jats:styled-content>\u2010IBS<\/jats:styled-content> and reported some symptoms like abdominal pain, bloating and exacerbation by dairy products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1440-1746.2012.07259.x","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T13:01:30Z","timestamp":1347973290000},"page":"1825-1830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lactase persistence\/non\u2010persistence genetic variants in irritable bowel syndrome in an endemic area for lactose malabsorption"],"prefix":"10.1111","volume":"27","author":[{"given":"Sunil","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Science Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhat","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Science Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balraj","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Science Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Science Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday C","family":"Ghoshal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Science Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"73","article-title":"Lactose intolerance\u2014a review","volume":"53","author":"Ransome\u2010Kuti O","year":"1977","journal-title":"Postgrad. 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