{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:47:55Z","timestamp":1759402075091},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>To examine the differences in esophageal histopathology between non\u2010erosive reflux disease (NERD<\/jats:styled-content>) and reflux esophagitis (RE<\/jats:styled-content>), and to investigate whether baseline esophageal histopathology can predict the therapeutic response to proton pump inhibitors (PPI<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Method<\/jats:title>The subjects comprised 94 patients with NERD<\/jats:styled-content> (n<\/jats:italic>\u2009=\u200971) or mild RE<\/jats:styled-content> (n<\/jats:italic>\u2009=\u200923). Tissue was biopsied from 5\u2009cm above the squamo\u2010columnar junction (SCJ), and the degree or presence of nine histopathological markers was assessed. The patients were treated with rabeprazole (RPZ<\/jats:styled-content>) 10\u2009mg once daily for 4 weeks. If complete heartburn relief was not achieved, RPZ<\/jats:styled-content> was increased to 10\u2009mg twice daily for another 2 weeks, and then to 20\u2009mg twice daily for another 2 weeks if heartburn remained.<\/jats:p><\/jats:sec>Results<\/jats:title>Features of esophageal histopathology 5\u2009cm above the SCJ<\/jats:styled-content> differed between NERD<\/jats:styled-content> and RE<\/jats:styled-content> patients. The esophageal histopathology in patients unresponsive to RPZ<\/jats:styled-content> was characterized by Protein Gene Product (PGP<\/jats:styled-content>) 9.5 negativity in those with NERD<\/jats:styled-content>, and intraepithelial bleeding in those with RE<\/jats:styled-content>. In addition, the combination of dilated intercellular spaces (DIS<\/jats:styled-content>) (+)\/PGP<\/jats:styled-content> 9.5 (\u2212) was indicative of strong resistance to PPI<\/jats:styled-content> therapy in NERD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The therapeutic efficacy of PPI<\/jats:styled-content> can be predicted from the features of biopsied esophageal tissue. Factors predictive of resistance to treatment with PPI<\/jats:styled-content> are negativity for PGP<\/jats:styled-content> 9.5 in NERD<\/jats:styled-content> patients and intraepithelial bleeding in RE<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1440-1746.2012.07266.x","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T09:09:15Z","timestamp":1347959355000},"page":"479-487","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Histology of symptomatic gastroesophageal reflux disease: Is it predictive of response to proton pump inhibitors?"],"prefix":"10.1111","volume":"28","author":[{"given":"Hiroto","family":"Miwa","sequence":"first","affiliation":[{"name":"Division of Upper Gastroenterology Department of Internal Medicine Hyogo College of Medicine Nishinomiya 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