{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:39:44Z","timestamp":1766086784583},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T00:00:00Z","timestamp":1355875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>The development of end\u2010stage graft disease is suspected to be partially determined by an individual genetic background. The aim of our study was to determine the prevalence of YKL<\/jats:styled-content>\u201040\u2010gene polymorphism in hepatitis C virus (HCV)<\/jats:styled-content>\u2010positive patients and its impact on the incidence of acute cellular rejection (ACR<\/jats:styled-content>), graft fibrosis and antiviral treatment response.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 149 patients, who underwent liver transplantation for HCV<\/jats:styled-content>\u2010induced liver disease, were genotyped for YKL<\/jats:styled-content>\u201040 (rs4950928; G<\/jats:styled-content>\/C<\/jats:styled-content>) by TaqMan Genotyping Assay. The results were correlated with 616 post\u2010transplant graft biopsies regarding inflammation, fibrosis and evidence for ACR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>No association of YKL<\/jats:styled-content>\u201040\u2010gemotypes was observed regarding mean inflammation grade (P<\/jats:italic>\u2009=\u20090.216) and antiviral treatment outcome (P<\/jats:italic>\u2009=\u20090.733). However, the development of advanced fibrosis (F<\/jats:styled-content>3\u20104) was significantly faster in patients with YKL<\/jats:styled-content>\u201040\u2010G<\/jats:styled-content>\u2010allele: t(CC<\/jats:styled-content>)\u2009=\u20094.6 versus<\/jats:italic> t(CG<\/jats:styled-content>\/GG<\/jats:styled-content>)\u2009=\u20092.4 years; P<\/jats:italic>\u2009=\u20090.006. Patients with lower fibrosis (F<\/jats:styled-content>0\u20102) compared to advanced fibrosis (F<\/jats:styled-content>3\u20104) received significantly more frequent dual immunosuppression (calcineurin inhibitors [CNI<\/jats:styled-content>s]\/mofetile mycophenolate [MMF<\/jats:styled-content>] vs<\/jats:italic> CNI<\/jats:styled-content>s; P<\/jats:italic>\u2009=\u20090.003). ACR<\/jats:styled-content>\u2010occurrence was associated with YKL<\/jats:styled-content>\u201040\u2010genotypes (ACR<\/jats:styled-content>: CC<\/jats:styled-content>\u2009=\u200960.4%, CG<\/jats:styled-content>\u2009=\u200925.0% and GG<\/jats:styled-content>\u2009=\u200914.6% vs<\/jats:italic> non\u2010ACR<\/jats:styled-content>: CC<\/jats:styled-content>\u2009=\u200974.2%, CG<\/jats:styled-content>\u2009=\u200923.8% and GG<\/jats:styled-content>\u2009=\u20092.0%; P<\/jats:italic>\u2009=\u20090.009) and with gender compatibility between donor and recipient (P<\/jats:italic>\u2009=\u20090.012).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Fibrosis progression and ACR<\/jats:styled-content>\u2010incidence after transplantation for HCV<\/jats:styled-content>\u2010induced liver disease seem to be under genetic control. The negative impact of G<\/jats:styled-content>\u2010allele on post\u2010transplant events observed in our study, deserves attention and should be verified in larger liver transplantation\u2010cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1440-1746.2012.07270.x","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T13:15:05Z","timestamp":1347974105000},"page":"153-160","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["YKL<\/scp>\u201040\u2010gene polymorphism affects acute cellular rejection and fibrosis progression after transplantation for hepatitis C<\/scp> virus\u2010induced liver disease"],"prefix":"10.1111","volume":"28","author":[{"given":"Dennis","family":"Eurich","sequence":"first","affiliation":[{"name":"General, Visceral and Transplantation Surgery Charit\u00e9 Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf P","family":"Neumann","sequence":"additional","affiliation":[{"name":"General, Visceral and Transplantation Surgery University Aachen Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Boas\u2010Knoop","sequence":"additional","affiliation":[{"name":"General, Visceral and Transplantation Surgery Charit\u00e9 Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Neuhaus","sequence":"additional","affiliation":[{"name":"General, Visceral and Transplantation Surgery Charit\u00e9 Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Kiessling","sequence":"additional","affiliation":[{"name":"General, Visceral and Transplantation Surgery Charit\u00e9 Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Yahyazadeh","sequence":"additional","affiliation":[{"name":"General, Visceral and Transplantation Surgery Charit\u00e9 Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Trautwein","sequence":"additional","affiliation":[{"name":"Medical Department III University Hospital Aachen RWTH Aachen Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Wasmuth","sequence":"additional","affiliation":[{"name":"Medical Department III University Hospital Aachen RWTH Aachen Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gero","family":"Puhl","sequence":"additional","affiliation":[{"name":"General, Visceral and Transplantation Surgery Charit\u00e9 Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Neuhaus","sequence":"additional","affiliation":[{"name":"General, Visceral and Transplantation Surgery Charit\u00e9 Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Bahra","sequence":"additional","affiliation":[{"name":"General, Visceral and Transplantation Surgery Charit\u00e9 Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000101738.27552.9D"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401163"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971069"},{"key":"e_1_2_6_5_1","first-page":"337","article-title":"Recurrent allograft disease: viral hepatitis","volume":"68","author":"Berenguer M","year":"2005","journal-title":"Acta Gastroenterol Belg."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.06.029"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0055"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21646"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07179.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22235"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.6253"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1744-313X.1998.tb01146.x","article-title":"Human cytokine gene nucleotide sequence alignments, 1998","volume":"25","author":"Bidwell JL","year":"1998","journal-title":"Eur. 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