{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:57:53Z","timestamp":1792443473852,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T00:00:00Z","timestamp":1355875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To evaluate presence of sero\u2010negative spondyloarthritis (<jats:styled-content style=\"fixed-case\">SpA<\/jats:styled-content>) in celiac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) patients, and whether compliance with a gluten free diet (<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>) improved arthritis manifestations in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a prospective, questionnaire based, cross\u2010sectional cohort study to evaluate the presence or absence of <jats:styled-content style=\"fixed-case\">SpA<\/jats:styled-content> simultaneously in both <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>356\/590 (60.3%) patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> participated in this study. 99% had diagnosis confirmed by a diagnostic test (79% small bowel biopsy, 19.8% blood test, 3.9% stool test). Approximately 131 (37%) cases of arthritis were reported in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients. Of the 6\/356 <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients with seronegative spondyloarthritides, four had sacroiliitis, two ankylosing spondylitis, and one psoriatic arthritis, compared to one ankylosing spondylitis and five psoriatic arthritis in non\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. Osteoarthritis (89 <jats:italic>vs<\/jats:italic> 59, <jats:italic>P<\/jats:italic>\u2009=\u20090.93) was the most common diagnosis reported by respondents. More <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients with diarrhea (94%) and anemia (81%) improved on <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>, compared to arthritis symptoms (30%). Autoimmune thyroiditis (10.6% <jats:italic>vs<\/jats:italic> 0.4%), insulin dependent diabetes mellitus (<jats:styled-content style=\"fixed-case\">IDDM<\/jats:styled-content>) (2.2% <jats:italic>vs<\/jats:italic> 1.7%), systemic Lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE)<\/jats:styled-content> (1.1% <jats:italic>vs<\/jats:italic> 0), and psoriasis (12.9% <jats:italic>vs<\/jats:italic> 5.5%) occurred more frequently in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients. The prevalence of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease, ulcerative colitis, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>jogren's syndrome, primary biliary cirrhosis, and primary sclerosing cholangitis was around 1% each. Univariate Logistic regression analysis showed \u2264\u2009high school education (odds ratio [<jats:styled-content style=\"fixed-case\">OR]<\/jats:styled-content> 2.01, <jats:italic>P &lt;<\/jats:italic>\u20090.003), age\u2009\u2265\u200960 years (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.13, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and osteoporosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.78, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) to be significantly associated with report of arthritis in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We did not find a high rate of SpA in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients. In contrast, increased rates of autoimmune thyroiditis, <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">IDDM<\/jats:styled-content>, and psoriasis were seen in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1440-1746.2012.07272.x","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T13:15:10Z","timestamp":1347974110000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Celiac disease arthropathy and autoimmunity study"],"prefix":"10.1111","volume":"28","author":[{"given":"Tariq","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Rheumatology The Ottawa Hospital  Sudbury Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukarram A","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine The Northern Ontario School of Medicine Laurentian University  Sudbury Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Community Medicine University of Ottawa Heart Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Karsh","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Rheumatology The Ottawa Hospital  Sudbury Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.12.1314"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03507.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.12.025"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.1.148"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-006-0023-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.08.044"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181dfcffd"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.3.477"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2008.06.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0624-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.4.669"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9258-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010059124994"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/030097400750041424"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02208654"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050028"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-3285-4.10072-5"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.162"},{"key":"e_1_2_6_20_1","unstructured":"Statistics Canada.Health Fact Sheets: Arthritis 2009. 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