{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T20:21:08Z","timestamp":1769977268009,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T00:00:00Z","timestamp":1355875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Routine screening for paroxysmal nocturnal hemoglobinuria (PNH<\/jats:styled-content>) in patients with Budd\u2010Chiari syndrome (BCS<\/jats:styled-content>) or portal vein thrombosis (PVT<\/jats:styled-content>) has been recommended in Western countries. However, little is known about whether the routine screening test should be necessary in Chinese patients with BCS<\/jats:styled-content> or PVT<\/jats:styled-content>. We conducted a prospective observational study to examine the prevalence of PNH<\/jats:styled-content> in these patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with primary BCS<\/jats:styled-content> or non\u2010malignant PVT<\/jats:styled-content> who were consecutively admitted to our department or regularly followed up between S<\/jats:styled-content>eptember 2009 and D<\/jats:styled-content>ecember 2011 were eligible for the study and detected the expression of CD55 and CD59 on erythrocytes and granulocytes. The CD55 or CD59 deficiency was considered as the proportion of erythrocytes or granulocytes with normal expression of CD55 or CD59 was less than 90%. PNH<\/jats:styled-content> was diagnosed by both CD55 and CD59 deficient clone at flow cytometry of peripheral blood cells.<\/jats:p><\/jats:sec>Results<\/jats:title>CD55 and\/or CD59 deficiencies were found in 1.6% (2\/127) of patients with primary BCS<\/jats:styled-content>, 1.0% (1\/100) of non\u2010malignant and non\u2010cirrhotic patients with PVT<\/jats:styled-content>, and 4.7% (4\/85) of cirrhotic patients with PVT<\/jats:styled-content>. Only one patient had both CD55 and CD59 deficiencies on granulocytes. But he had been diagnosed with PNH<\/jats:styled-content> before BCS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>P<\/jats:styled-content>aroxysmal nocturnal hemoglobinuria was very rare in Chinese patients with BCS<\/jats:styled-content> or PVT<\/jats:styled-content>, suggesting that routine screening for PNH<\/jats:styled-content> should not be indiscriminately performed in such patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1440-1746.2012.07282.x","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T13:40:30Z","timestamp":1349012430000},"page":"148-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Prevalence of paroxysmal nocturnal hemoglobinuria in C<\/scp>hinese patients with B<\/scp>udd\u2010C<\/scp>hiari syndrome or portal vein thrombosis"],"prefix":"10.1111","volume":"28","author":[{"given":"Xingshun","family":"Qi","sequence":"first","affiliation":[{"name":"Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuangye","family":"He","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohong","family":"Han","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanxin","family":"Yin","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Wu","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hightrust Diagnostics Laboratory Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Niu","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaichun","family":"Wu","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiming","family":"Fan","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22772"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60004-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-010-0413-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328351c348"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.01.046"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2007.05.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1717"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1160\/TH07-11-0664","article-title":"Temporal trends in mortality rates from visceral vein thrombosis in paroxysmal nocturnal haemoglobinuria: an optimistic view","volume":"99","author":"Poulou LS","year":"2008","journal-title":"Thromb. 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