{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:58:57Z","timestamp":1776135537102,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T00:00:00Z","timestamp":1355875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Combined hepatocellular\u2010cholangiocarcinoma (CHC<\/jats:styled-content>) is a rare liver malignancy. In this study, we compared patient characteristics and outcomes for primary CHC<\/jats:styled-content>, intrahepatic cholangiocarcinoma (ICC<\/jats:styled-content>), and hepatocellular carcinoma (HCC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Medical records of patients with tissue\u2010proven CHC<\/jats:styled-content> (65 cases) treated at the C<\/jats:styled-content>hang G<\/jats:styled-content>ung M<\/jats:styled-content>emorial H<\/jats:styled-content>ospital between 1991 and 2005 were retrospectively reviewed. These records were compared to records of patients diagnosed with tissue\u2010proven HCC<\/jats:styled-content> (1985 cases) and ICC<\/jats:styled-content> (127 cases) during the same period.<\/jats:p><\/jats:sec>Results<\/jats:title>Hepatitis B<\/jats:styled-content> and C<\/jats:styled-content> are major causes of CHC<\/jats:styled-content>. CHC<\/jats:styled-content> patients exhibited greater similarity to HCC<\/jats:styled-content> than to ICC<\/jats:styled-content> patients with respect to cirrhotic changes, age, and positive serology for hepatitis B<\/jats:styled-content> surface antigen and anti\u2010hepatitis C<\/jats:styled-content> antibody. Survival was related to tumor characteristics and intervention therapies, but not to etiologies.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The clinical characteristics of CHC<\/jats:styled-content> are similar to those of HCC<\/jats:styled-content>, but overall survival is more similar to that of ICC<\/jats:styled-content>; survival may be related to tumor biology rather than the cause. Multimodal treatment with an initial aggressive therapeutic approach can improve survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1440-1746.2012.07289.x","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T11:39:11Z","timestamp":1349350751000},"page":"122-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Comparison of clinical characteristics of combined hepatocellular\u2010cholangiocarcinoma and other primary liver cancers"],"prefix":"10.1111","volume":"28","author":[{"given":"Chern\u2010Horng","family":"Lee","sequence":"first","affiliation":[{"name":"Division of General Medicine Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen\u2010Yung","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Chang Gung Medical College University School of Medicine Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee\u2010Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Biostatistical Center for Clinical Research Chang Gung Memorial Hospital Taoyuan Taiwan"},{"name":"Chang Gung Medical College University School of Medicine Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Jr","family":"Lin","sequence":"additional","affiliation":[{"name":"Biostatistical Center for Clinical Research Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-006-3276-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005350050140"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-006-1117-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19961015)78:8<1671::AID-CNCR6>3.0.CO;2-H"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.03.018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181ce5dfa"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605063"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00542.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-002-0714-y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2006.01.018"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90084-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850101)55:1<124::AID-CNCR2820550120>3.0.CO;2-Z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/917356"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-828889"},{"key":"e_1_2_7_16_1","first-page":"113","article-title":"Consideration of the role of radiotherapy for unresectable intrahepatic cholangiocarcinoma: a retrospective analysis of 75 patients","volume":"12","author":"Zeng ZC","year":"2006","journal-title":"Cancer J."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602590"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-68177-9_4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1385\/SCR:1:3:253"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1998.tb00168.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02929.x"},{"key":"e_1_2_7_22_1","first-page":"1317","article-title":"Differences in prognostic factors according to viral status in patients with hepatocellular carcinoma","volume":"23","author":"Akahoshi H","year":"2010","journal-title":"Oncol. 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