{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:15:52Z","timestamp":1790162152721,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:00:00Z","timestamp":1155859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Aim:\u2003<\/jats:bold> To compare the long\u2010term growth and neurodevelopmental outcomes at 36\u2003months adjusted age in preterm infants (birthweight (BW)\u2003\u2264\u20031250\u2003g) with necrotising enterocolitis (NEC) with BW\u2010matched controls.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> This is a case control study performed at a regional tertiary care neonatal intensive care unit. Infants with stage II or III NEC admitted to a regional tertiary care neonatal unit between 1995 and 2000 were identified. Each infant with NEC was matched by BW (\u00b1100\u2003g) to next two infants admitted in the unit without NEC. Growth and neurodevelopmental outcomes at 36\u2003months are compared.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> In total, 51 infants with NEC and 102 controls met study eligibility criteria and 146\/153 (94.3%) were prospectively followed for 36\u2003months. Infants with NEC had more culture\u2010proven sepsis (35.3% vs. 10.8%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001); patent ductus arteriosus requiring therapy (64.7% vs. 45%, <jats:italic>P<\/jats:italic>\u2003=\u20030.02), chronic lung disease (60.7% vs. 45%, <jats:italic>P<\/jats:italic>\u2003=\u20030.04) and longer hospital stay (84\u2003days vs. 71\u2003days, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). There were no significant differences in growth outcomes between the two groups at 36\u2003months. Overall 24% of infants with NEC had one major neurodevelopmental disability compared with 10% among control infants. Infants who developed NEC had significantly higher cognitive delay (i.e. cognitive index &lt;70) and visual impairment. A logistic regression model identified NEC as a predictor of cognitive delay.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Preterm infants who develop NEC are at a significantly higher risk for developing neurodevelopmental disability. We recommend close neurodevelopmental follow up for all \u22641250\u2003g infants who develop stage II or III NEC.<\/jats:p>","DOI":"10.1111\/j.1440-1754.2006.00910.x","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T10:32:05Z","timestamp":1155897125000},"page":"499-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Does necrotising enterocolitis impact the neurodevelopmental and growth outcomes in preterm infants with birthweight \u22641250\u2003g?"],"prefix":"10.1111","volume":"42","author":[{"given":"Amuchou S","family":"Soraisham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish J","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Y","family":"Al\u2010Hindi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginald S","family":"Sauve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70413-2"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30353-1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13236.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90092-6"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200410000-00012"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.1.e1"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1542\/peds.91.3.540","article-title":"The Vermont\u2010Oxford Trials Network: very low birth weight outcomes for 1990","volume":"91","author":"The investigators of the Vermont\u2010Oxford Trials Network Database Projects.","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82418-7"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770210"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1542\/peds.84.5.808","article-title":"Severity of necrotizing enterocolitis: influence on outcome at 2\u2003years of age","volume":"84","author":"Walsh MC","year":"1989","journal-title":"Pediatrics"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00332.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211165"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050648"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0569"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060070042025"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb08895.x"},{"key":"e_1_2_7_20_2","first-page":"385","article-title":"Cerebral palsy diagnosis in children over age 1\u2003year: standard criteria","volume":"61","author":"Levine MS","year":"1980","journal-title":"Arch. 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