{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:45:28Z","timestamp":1791146728039,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T00:00:00Z","timestamp":1161129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Aim:\u2003<\/jats:bold> To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> A double\u2010blind, randomised cross\u2010over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, Modified Tardieu Scale and parent questionnaire.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Fifteen children with mean age 7.4\u2003years (SD\u2003=\u20032.7\u2003years) and spastic or spastic\/dystonic quadriplegia (Gross Motor Function Classification System Level IV or V) were enrolled. Children scored significantly better on the Goal Attainment Scale with baclofen compared with placebo (<jats:italic>F<\/jats:italic><jats:sub>(1,13)<\/jats:sub>\u2003=\u20034.5, <jats:italic>P<\/jats:italic>\u2003=\u20030.05). There was no significant difference between baclofen and placebo for the Pediatric Evaluation of Disability Inventory or Modified Tardieu Scale. Parent questionnaire results are described.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> This pilot study demonstrates that oral baclofen has an effect beyond placebo in improving goal\u2010oriented tasks, such as transfers, in children with spastic quadriplegic cerebral palsy.<\/jats:p>","DOI":"10.1111\/j.1440-1754.2006.00957.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T19:50:26Z","timestamp":1161201026000},"page":"715-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Oral baclofen in children with cerebral palsy: A double\u2010blind cross\u2010over pilot study"],"prefix":"10.1111","volume":"42","author":[{"given":"Adam","family":"Scheinberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence T","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"O\u2019Flaherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,18]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7396.970"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401203300308"},{"key":"e_1_2_8_4_2","volume-title":"Cerebral Palsies: Epidemiology and Causal Pathways","author":"Stanley F","year":"2000"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073896011001S01"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/03790798709166357"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073803018001S0801"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1966.tb01824.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1975.tb04697.x"},{"key":"e_1_2_8_10_2","first-page":"398","article-title":"A controlled trial of baclofen in children with cerebral palsy","volume":"5","author":"Milla PJ","year":"1977","journal-title":"J. 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