{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:05:29Z","timestamp":1790982329279,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T00:00:00Z","timestamp":1163030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Aims:\u2003<\/jats:bold> To study the incidence of hypernatraemia (plasma sodium &gt;145\u2003mmol\/L), identify predisposing factors to and associated complications of hypernatraemia in preterm infants born less than 27\u2003weeks gestation in the first 5\u2003days of life.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Preterm infants less than 27\u2003week gestation over an 18\u2010month period were studied by retrospective analysis of patient records. Data were collected on gestation, birthweight, sex, antenatal steroid use, phototherapy, incubator humidity, time of transfer to incubator, plasma sodium, urea and creatinine. Actual fluid and sodium intake was calculated for the first 5\u2003days of life. Data were collected on chronic lung disease, patent ductus arteriosus, intraventricular haemorrhage, necrotising enterocolitis and death.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> In this study 46 (69.7%) of 66 infants studied developed hypernatraemia (&gt;145\u2003mmol\/L), occurring most frequently between 24 and 48\u2003h of age. The median gestation of hypernatraemic babies was significantly lower. There was no significant difference in median birthweight, or factors associated with increased insensible water loss between the hypernatraemic and the non\u2010hypernatraemic groups. Fluid intake was significantly higher on days 2, 3 and 4 in the hypernatraemic group. There was no difference in sodium intake between the two groups. More hypernatraemic babies compared with controls developed chronic lung disease, patent ductus arteriosus, significant intraventricular haemorrhage, necrotising enterocolitis and died, but was not significant.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Hypernatraemia occurs commonly in preterm infants less than 27\u2003weeks gestation and was not associated with significant morbidity. The more immature infants developed hypernatraemia and all cases resolved after increasing fluid intake.<\/jats:p>","DOI":"10.1111\/j.1440-1754.2006.00975.x","type":"journal-article","created":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T14:18:14Z","timestamp":1163081894000},"page":"771-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Hypernatraemia in preterm infants born at less than 27\u2003weeks gestation"],"prefix":"10.1111","volume":"42","author":[{"given":"Zuzanna","family":"Gawlowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra","family":"Aladangady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro G","family":"Coen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.87.3.F158"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.5.423"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80078-4"},{"key":"e_1_2_7_5_2","first-page":"75","article-title":"Hypernatraemia in the very low birth weight infant","volume":"4","author":"Harkavy KL","year":"1983","journal-title":"Int. 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