{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:56:49Z","timestamp":1777485409329,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T00:00:00Z","timestamp":1163030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Aim:\u2003<\/jats:bold> We aimed to determine the laboratory detection time of bacteraemia in neonatal blood cultures, and whether this differed by: organism; samples deemed to represent true bacteraemia versus contaminants; and blood cultures collected from an infant &lt;48\u2003h of age (early) or \u226548\u2003h of age (late).<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> A retrospective audit of all positive blood cultures collected from neonates in the Grantley Stable Neonatal Unit, Royal Women\u2019s Hospital, Brisbane, between 1 January 2000 and 31 December 2004 was undertaken. The bacteraemia detection method used was the BacTAlert system with Peds bottles.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Two hundred and three positive blood cultures were included in the analysis. One hundred and sixteen (57%) were deemed septicaemia, 87 (43%) were deemed contaminants. The median (interquartile range) time to positivity for positive blood cultures deemed septicaemia and contaminants were 15.9 (11.6, 22.2) and 30.2 (20.4, 43.9)\u2003h, respectively. Fifty\u2010six (28%) positive blood cultures were collected when infants were &lt;48\u2003h of age and 147 (72%) were collected in infants \u226548 h of age. <jats:italic>Post hoc<\/jats:italic> analysis revealed that the time to positivity for early septicaemia was 13.7 (11, 16.7)\u2003h; early contaminant was 25.2 (19.2, 33.8)\u2003h; late septicaemia was 17.2 (12.2, 23.4)\u2003h; and late contaminant was 37.9 (21.7, 51.2)\u2003h. The time to positivity for: Group B streptococcus was 9.3 (8.2, 11.0)\u2003h; <jats:italic>Escherichia coli<\/jats:italic> was 11.3 (10.0, 13.5)\u2003h; and coagulase\u2010negative staphylococci was 28.9 (20.5, 41.2)\u2003h.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> The incubation time for positive blood cultures significantly differs by organism type and whether they are considered early or late septicaemia versus contaminants. We recommend that: infants who are &lt;48\u2003h of age at the time of blood culture collection, who remain clinically well and have negative cultures 36\u2003h after the initial collection can safely have their antibiotic treatment ceased; infants who are \u226548\u2003h of age at the time of collection should continue antibiotic treatment for at least 48\u2003h before cessation is considered.<\/jats:p>","DOI":"10.1111\/j.1440-1754.2006.00980.x","type":"journal-article","created":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T14:18:14Z","timestamp":1163081894000},"page":"797-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Incubation time required for neonatal blood cultures to become positive"],"prefix":"10.1111","volume":"42","author":[{"given":"Luke","family":"Jardine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Faoagali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,9]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"248","volume-title":"Infectious Diseases of the Fetus and Newborn Infant","author":"Pazzi D","year":"2006"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.2.e18"},{"key":"e_1_2_7_4_2","first-page":"97","article-title":"Neonatal septicaemia: bacteriological aspects and outcome in the University hospital center of Lome","volume":"97","author":"Balaka B","year":"2004","journal-title":"Bull. 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Wkly Rep."},{"key":"e_1_2_7_19_2","volume-title":"The Report of the Australian and New Zealand Neonatal Network, 2003","author":"Abeywardana S","year":"2005"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1754.2006.00980.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1754.2006.00980.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T07:53:07Z","timestamp":1697356387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1754.2006.00980.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,9]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1440-1754.2006.00980.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1754.2006.00980.x","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,9]]},"assertion":[{"value":"2006-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}