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Nevertheless, GBS remains a leading cause of neonatal sepsis in Australia and New Zealand resulting in considerable morbidity and mortality, particularly among preterm infants. In the United States, the universal screening\u2010based approach for identifying women for IAP results in apparently lower rates of early\u2010onset neonatal GBS infection than risk\u2010based assessment. In addition, IAP has altered the profile of newborn infants who develop early\u2010onset disease. Many affected infants lack the typical intrapartum risk factors for GBS infection, are born to mothers with a negative GBS screen or represent missed opportunities for prevention. Clinicians should remain alert for signs of sepsis in any newborn infant. We provide an update of GBS preventative management strategies in the perinatal period taking into account recent United States, Australian and New Zealand guidelines.<\/jats:p>","DOI":"10.1111\/j.1440-1754.2011.02203.x","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T11:14:40Z","timestamp":1323774880000},"page":"808-815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prevention of neonatal group B streptococcus disease in the 21st century"],"prefix":"10.1111","volume":"48","author":[{"given":"Vanessa","family":"Clifford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M","family":"Garland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Grimwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,13]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000128782.20060.79"},{"key":"e_1_2_11_3_2","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease \u2013 revised guidelines from CDC, 2010","volume":"59","author":"Verani JR","year":"2010","journal-title":"MMWR Recomm. 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