{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:50:25Z","timestamp":1774878625523,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:00:00Z","timestamp":1331078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>Aim:\u2003<\/jats:bold> Investigate the incidence, etiological pattern and the antimicrobial resistance of late\u2010onset neonatal infections over a period of 5\u2003years.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Longitudinal audit of neonatal sepsis from January 2005 to December 2009, in the main maternity hospital in Kuwait. Late\u2010onset neonatal infection was defined as the culture of a single potentially pathogenic organism from blood or cerebrospinal fluid from an infant older than 6\u2003days in association with clinical or laboratory findings consistent with infection.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> The overall incidence was 16.9 (95% confidence interval: 15.8\u201318.0) episodes per 1000 live births. The commonest pathogen was coagulase\u2010negative <jats:italic>Staphylococcus<\/jats:italic>, 339 (35.7%), while <jats:italic>Klebsiella<\/jats:italic> was the most common gram\u2010negative infection, 178 (18.8%). <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Enterococcus<\/jats:italic> and <jats:italic>Enterobacter<\/jats:italic> spp were each responsible for 6% of all infections. <jats:italic>Candida<\/jats:italic> caused 104 (11.0%) infections. The general pattern of infection remained unchanged over the study period. Case fatality was 11.7% (95% confidence interval: 9.7\u201313.9%) and was high for <jats:italic>Pseudomonas<\/jats:italic> (18.4%) and <jats:italic>Candida<\/jats:italic> (22.1%) infections. Approximately 24 and 20% of <jats:italic>Klebsiella<\/jats:italic> infections were resistant to cefotaxime and gentamicin, respectively, while 28 and 24% of <jats:italic>Escherichia coli<\/jats:italic> infections were resistant to cefotaxime and gentamicin, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> The incidence of late\u2010onset infection in Kuwait is high, resembling that in resource\u2010poor countries. The high incidence coupled with low case fatality provides an example for settings where tertiary care is introduced without strict measures against nosocomial infections. Prevention against nosocomial infections in neonatal units has the potential to further reduce neonatal mortality in these settings.<\/jats:p>","DOI":"10.1111\/j.1440-1754.2012.02432.x","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T12:49:53Z","timestamp":1331124593000},"page":"604-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Incidence, aetiology and resistance of late\u2010onset neonatal sepsis: A five\u2010year prospective study"],"prefix":"10.1111","volume":"48","author":[{"given":"Majeda S","family":"Hammoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Al\u2010Taiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukman","family":"Thalib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noura","family":"Al\u2010Sweih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Pathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,7]]},"reference":[{"issue":"3","key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1542\/peds.98.3.357","article-title":"Nosocomial infections among neonates in high\u2010risk nurseries in the United States. 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