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NAIT results from trans\u2010placental passage of maternal antibodies against a paternally derived fetal platelet alloantigen. Clinical presentation varies from unexpected thrombocytopenia on a blood film in a well newborn to intracranial haemorrhage (ICH). In contrast to haemolytic disease of the newborn, NAIT can present in a first pregnancy, and subsequent pregnancies are usually more severely affected. The role of antenatal screening for maternal alloantibodies instead of fetal blood sampling to identify at\u2010risk fetuses remains uncertain, but there is a trend towards less invasive maternally directed treatment for at\u2010risk pregnancies. Neonatal management is aimed at preventing or limiting thrombocytopenic bleeding with transfusion of antigen\u2010matched platelets.<\/jats:p>","DOI":"10.1111\/j.1440-1754.2012.02528.x","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T03:48:10Z","timestamp":1347508090000},"page":"816-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Review of neonatal alloimmune thrombocytopenia"],"prefix":"10.1111","volume":"48","author":[{"given":"David C","family":"Risson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn A","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,12]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2003.00331.x"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2824.2007.00070.x"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04026.x"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01208.x"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00606.x"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2008.05.003"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2002.00371.x"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2009.02339.x"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2280"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91733-9"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb02567.x"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-211839"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-040121"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-284919"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-299404"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/156867"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0582"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348383"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00628.x"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2008.03.004"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03380.x"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20282"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200003000-00025"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.12.4402"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1995.tb02541.x"},{"key":"e_1_2_12_27_2","unstructured":"(QLD) ARCBS.Platelet Immunology Reference Laboratory Manual.2009."},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2003.00302.x"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2001.tb01293.x"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/875647939200800504"},{"key":"e_1_2_12_31_2","first-page":"1457","article-title":"Neonatal alloimmune thrombocytopenia: antenatal and postnatal imaging findings in the pediatric brain","volume":"23","author":"Dale ST","year":"2002","journal-title":"AJNR Am. 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