{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T22:38:59Z","timestamp":1774996739601,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T00:00:00Z","timestamp":1077753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p>The present report concerns an autopsy case of CJD showing typical clinical features of CJD. The patient was a Japanese woman without hereditary burden or dementing disorder anamnesis who was 70\u2010years\u2010old at the time of death. She developed gait disturbance at age 68, followed by memory impairment, visual disturbance, and myoclonus. A neurological examination approximately 2\u2003months after the disease onset revealed akinetic mutism, in addition to periodic synchronous discharges on electroencephalogram. Serial neuroradiological examinations disclosed progressive atrophy of the brain. She died of bronchopneumonia 25\u2003months after the disease onset. The brain weighed 560\u2003g (cerebrum 490\u2003g, brainstem with cerebellum 70\u2003g). Macroscopically, neuropathological examination showed prominent atrophy of the cerebrum, caudate nucleus, and cerebellum, in addition to necrosis of the cerebral white matter, compatible with panencephalopathic CJD. Histologically, there was neuronal loss with or without spongiform change in the cerebral cortex, parahippocampal gyrus, amygdala, striatum, pallidum, thalamus, pontine nucleus, and cerebellar granule cells, in addition to diffuse synaptic\u2010type prion staining in the cerebrum and cerebellum. Furthermore, senile plaques, compatible with definite Consortium to establish a registry for Alzheimer's disease rank Alzheimer's disease, and neurofibrillary changes of the limbic system, consistent with stage IV of Braak's classification, were found. Based on these clinicopathological findings and a review of the published literature, it is concluded that there were two forms of coexistence of CJD and Alzheimer's disease in the same patient.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2003.00513.x","type":"journal-article","created":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T14:40:48Z","timestamp":1077806448000},"page":"46-55","source":"Crossref","is-referenced-by-count":35,"title":["Coexistence of CJD and Alzheimer's disease: An autopsy case showing typical clinical features of CJD"],"prefix":"10.1111","volume":"24","author":[{"given":"Kuniaki","family":"Tsuchiya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"Yagishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Taki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadakiyo","family":"Watabiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Mizusawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1995.tb00625.x"},{"key":"e_1_2_5_3_2","first-page":"271","article-title":"The primary structure of the prion protein influences the distribution of abnormal prion protein in the central nervous system","volume":"141","author":"Kitamoto T","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1995.tb00575.x"},{"key":"e_1_2_5_5_2","first-page":"81","article-title":"Degeneration of the thalamus and inferior olives associated with spongiform encephalopathy of the cerebral cortex","volume":"7","author":"Mizusawa H","year":"1988","journal-title":"Clin Neuropathol"},{"key":"e_1_2_5_6_2","first-page":"202","article-title":"Association de maladies d\u2019Alzheimer et de Creutzfeldt\u2010Jakob","volume":"77","author":"Gaches J","year":"1977","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.3.535"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427210"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340609"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.3.559"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00713522"},{"key":"e_1_2_5_12_2","first-page":"923","article-title":"Creutzfeldt\u2010Jakob disease with Kuru\u2010like plaques in Japan","volume":"31","author":"Yagishita S","year":"1981","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.8.1641"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2001.00407.x"},{"key":"e_1_2_5_15_2","first-page":"1285","article-title":"Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt\u2010Jakob disease","volume":"140","author":"Kitamoto T","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550090125018"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390613"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W"},{"key":"e_1_2_5_19_2","first-page":"1259","article-title":"An autopsy case of ataxic form of Creutzfeldt\u2010Jakob disease with amnestic syndrome as an initial sign with special reference to the problem of the cerebellar sign in this disease","volume":"12","author":"Tsuchiya K","year":"1994","journal-title":"Pathol Clin Med"},{"key":"e_1_2_5_20_2","first-page":"82","article-title":"An autopsy case of ataxic form of Creutzfeldt\u2010Jakob disease (C\u2010JD) with localized cerebellar cortical lesion; 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