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Therefore, on the basis of clinicopathologic features, atypical progressive supranuclear palsy was diagnosed. In addition, the brain tissue of the present patient was investigated with an antibody specific for four\u2010repeat tau (4R\u2010tau). In the precentral cortex, numerous tau\u2010positive tufted astrocytes, pretangles, and threads were positive for 4R\u2010tau. Using a confocal microscopy we demonstrated that tufted astrocytes positive for 4R\u2010tau were adjacent to astrocytes positive for GFAP. The present findings suggest that accumulation of four\u2010repeat tau in astrocytes is a degenerative process rather than a reactive process.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2003.00529.x","type":"journal-article","created":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T14:40:48Z","timestamp":1077806448000},"page":"60-65","source":"Crossref","is-referenced-by-count":10,"title":["Glial localization of four\u2010repeat tau in atypical progressive supranuclear palsy"],"prefix":"10.1111","volume":"24","author":[{"given":"Yumiko","family":"Motoi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Takanashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Itaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikuni","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,26]]},"reference":[{"issue":"2","key":"e_1_2_6_2_2","first-page":";","article-title":"Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration","volume":"246","author":"Dickson DW","year":"1999","journal-title":"J Neurol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01542-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90117-V"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90196-G"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90028-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199706000-00010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050911"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s004010000283","article-title":"Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy","volume":"101","author":"Arai T","year":"2001","journal-title":"Acta Neuropathol (Berl)"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004019900177"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90145-W"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227727"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00401-002-0569-x","article-title":"Tau accumulation in astrocytes in progressive supranuclear palsy is a degenerative rather than a reactive process","volume":"104","author":"Togo T","year":"2002","journal-title":"Acta Neuropathol (Berl)"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1789.2003.00529.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1789.2003.00529.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T17:43:07Z","timestamp":1696959787000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1789.2003.00529.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,26]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1111\/j.1440-1789.2003.00529.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1789.2003.00529.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,26]]}}}