{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:26:08Z","timestamp":1777645568267,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T00:00:00Z","timestamp":1077753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p>Nine cases of atypical Pick's disease without Pick bodies were investigated immunohistochemically. Ubiquitin (ub)\u2010positive and tau\u2010negative structures were mainly found in the cerebral cortex and hippocampal dentate gyrus. In the cerebral cortex, most of the ub\u2010positive structures had ub\u2010positive dendrites in the neuropil, although some also showed diffuse ub\u2010positive staining in the neuronal cytoplasm. These ub\u2010positive structures were distributed throughout layers II\u2010IIIab and layers V\u2010VI. Granular cells of the dentate gyrus had ub\u2010positive intraneuronal inclusions. When the numbers of ub\u2010positive neurons and dendrites were evaluated in relation to the degree of neuronal loss in the cerebral cortex, the number of ub\u2010positive neurons was significantly lower in regions showing very mild neuronal loss and higher in regions showing moderate neuronal loss. In contrast, ub\u2010positive dendrites were detected even in cortical regions showing very mild neuronal loss. Immunoelectron\u2010microscopically, ub\u2010positive structures contained ub\u2010positive ribosome\u2010like granular components in the neuronal cytoplasm and dendrites, which were occasionally related to the rough endoplasmic reticulum and accompanied by a few filamentous components. Almost all ub\u2010positive structures were positive for ub\u2010binding protein p62 in double\u2010immunostaining method. Some ub\u2010positive or negative neurons in the cerebral cortex were positively immunolabeled with anti\u2010ub ligase (Parkin) and anti\u2010ub C\u2010terminal hydrolase antibodies, whereas dendrites were not labeled by these antibodies. From the present study, it is suggested that in the cerebral cortex, these ubiquitinated proteins may firstly accumulate in the dendrites at the onset of neuronal degeneration, then appear in the neuronal cytoplasm before finally disappearing with neuronal loss.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2003.00538.x","type":"journal-article","created":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T14:40:48Z","timestamp":1077806448000},"page":"38-45","source":"Crossref","is-referenced-by-count":9,"title":["Ubiquitin and ubiquitin\u2010related proteins in neurons and dendrites of brains of atypical Pick's disease without Pick 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