{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:42:54Z","timestamp":1790818974203,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T00:00:00Z","timestamp":1093564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p>Pathological changes of cerebral microvessels in transient ischemia were investigated by scanning electron microscopy of vascular corrosion casts. Wistar rats were treated with middle cerebral artery (MCA) occlusion for 30\u2003min, 1\u2003h, \u200a3\u2003h, \u200a4\u2003h, \u200a5\u2003h \u200aor \u200a7\u2003h \u200aand \u200asubsequent \u200areperfusion \u200afor 2\u2003h. The ultrastructures of the cast were observed and computer\u2010aided montage micrographs were obtained for visualization of the whole microvasculature in the ischemic brain hemisphere. Avascular areas representing ischemic areas were detected in the frontotemporal cortex and caudate putamen in the groups from 30\u2003min to 5\u2003h occlusion. Extravasation of the resin, which probably corresponded to the leakage of plasma or hemorrhage, was seen as spheroidal, conglomerative, large massive and worm\u2010like types. The spheroidal type, which probably indicated a small leakage or minor hemorrhage, began to appear in the 30\u2010min occlusion group. The conglomerative type, which probably indicated a larger leakage or moderate hemorrhage, appeared in the 3\u2010 to 5\u2010h occlusion groups. The large massive and worm\u2010like types, which probably indicated a significant hemorrhage, appeared in the 4\u2010 and 5\u2010h occlusion groups. The number of these extravasations increased significantly in the 4\u2010h occlusion group. Arterioles near the avascular area frequently showed vasospastic appearances, such as corrugations, fusiform indentations of endothelial nuclei, continuous circulatory constrictions and severe narrowing with interrupted branches. Arteriolar vasospasm possibly caused prolonged hypoperfusion even if reperfusion was achieved. The capillaries had a thin stringy appearance in the 4\u2010 and 5\u2010h occlusion groups. These changes seemed to relate closely with increased intracranial pressure by brain edema or hemorrhage. The present study suggested that the risk of brain edema or hemorrhagic infarction increased beyond 3\u2003h of MCA occlusion, and vasospasm of the arterioles might participate in stroke pathophysiology.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2004.00560.x","type":"journal-article","created":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T10:42:28Z","timestamp":1093603348000},"page":"219-227","source":"Crossref","is-referenced-by-count":31,"title":["Three\u2010dimensional structural changes in cerebral microvessels after transient focal cerebral ischemia in rats: Scanning electron microscopic study of corrosion 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