{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:11:25Z","timestamp":1705363885452},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T00:00:00Z","timestamp":1101427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>Semiquantitative morphological analysis of cerebral intraneuronal ubiquitin\u2010positive tau\u2010negative inclusions, a pathologic marker for motor neuron disease with dementia (MND\u2010D), was performed in the dentate gyrus and parahippocampal gyrus of 20 clinicopathologically confirmed patients with MND\u2010D. The forms of the inclusions were tentatively classified into three types: (i) C\u2010type, consisting of relatively large and intensely stained crescent or circular structures; (ii) L\u2010type, showing fine linear structures around the nuclei; and (iii) G\u2010type, showing faintly stained granular structures. The frequencies of the C\u2010type, L\u2010type and G\u2010type was 0.5\u20139.3%, 0.2\u20136.5% and 0\u20136.6% of dentate granule cells, respectively. In contrast to the dentate gyrus, almost all inclusions showed either the C\u2010type or L\u2010type form in the parahippocampal gyrus. A positive correlation was noted only between incidences of C\u2010type inclusion of the dentate gyrus and that of the parahippocampal gyrus (<jats:italic>r<\/jats:italic>\u2003=\u20030.69,<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The morphological differences of the inclusions probably reflect different stages of their formation.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2004.00567.x","type":"journal-article","created":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T16:46:13Z","timestamp":1101487573000},"page":"296-301","source":"Crossref","is-referenced-by-count":9,"title":["Morphological differences of intraneuronal ubiquitin\u2010positive inclusions in the dentate gyrus and parahippocampal gyrus of motor neuron disease with 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