{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:45:40Z","timestamp":1764402340571},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,8,29]],"date-time":"2005-08-29T00:00:00Z","timestamp":1125273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>We report the autopsy findings of a 62\u2010year\u2010old man who exhibited progressive FTD 10\u2003years before the appearance of muscle weakness and wasting, and who died approximately 11\u2003years after onset of the symptoms. Degeneration and atrophy of the frontal and temporal lobes, which contained ubiquitin\u2010positive neuronal inclusions and dystrophic neurites, were evident. Circumscribed degeneration affecting the hippocampal CA1\u2010subiculum border zone was also a feature. Moreover, degeneration was present in both the upper and lower motor neuron systems, the latter being more severely affected. A few lower motor neurons were found to contain the cytoplasmic inclusions characteristic of ALS (i.e. Bunina bodies and ubiquitin\u2010positive skeins). Also of interest was the presence of pallidonigroluysian atrophy, which appeared to be responsible for the chorea\u2010like involuntary movements that developed in this patient approximately 2\u2003months before death. The clinical and pathological features of our patient further support the idea that motor neuron disease\u2010inclusion dementia (MND\u2010ID), which has been classified as a pathological subgroup of FTD, is a<jats:italic>forme fruste<\/jats:italic>of ALS with dementia. In other words, if patients with MND\u2010ID live long enough, they may develop ALS.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2005.00599.x","type":"journal-article","created":{"date-parts":[[2005,8,30]],"date-time":"2005-08-30T06:58:00Z","timestamp":1125385080000},"page":"214-219","source":"Crossref","is-referenced-by-count":12,"title":["Is motor neuron disease\u2010inclusion dementia a<i>forme fruste<\/i>of amyotrophic lateral sclerosis with dementia? An autopsy case further supporting the disease concept"],"prefix":"10.1111","volume":"25","author":[{"given":"Yasuko","family":"Toyoshima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Feng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Kozakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/neur.1996.0046"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.2.217"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.9.953"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.11.1803"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1995.tb01095.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050505"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00168-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.267"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2003.00545.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010100457"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-001-0513-5"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00401-003-0696-z","article-title":"Pathological involvement of the motor neuron system and hippocampal formation in motor neuron disease\u2010inclusion dementia","volume":"106","author":"Toyoshima Y","year":"2003","journal-title":"Acta Neuropathol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00401-002-0655-0","article-title":"\u03b1\u2013Synuclein pathology affecting Bergmann glia of the cerebellum in patients with \u03b1\u2013synucleinopathoes","volume":"105","author":"Piao Y\u2010S","year":"2003","journal-title":"Acta Neuropathol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200101)49:1<14::AID-ANA5>3.0.CO;2-X"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.1998.00108.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.1998.tb00104.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2000.00272.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s004010000336","article-title":"Atypical amyotrophic lateral sclerosis with dementia mimicking frontal Pick's disease: a report of an autopsy case with a clinical course of 15 years","volume":"101","author":"Tsuchiya K","year":"2001","journal-title":"Acta Neuropathol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.1996.tb00150.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02034-1"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.3.306"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00698300"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(92)90044-L"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00454908"},{"key":"e_1_2_6_26_2","first-page":"241","article-title":"Motor neuron disease with involvement of the pallido\u2010luysio\u2010nigral system and mesencephalic tegmentum","volume":"14","author":"Kato S","year":"1995","journal-title":"Clin Neuropathol"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-001-0482-8"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1750-3639.2003.tb00002.x","article-title":"Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000","volume":"12","author":"Piao Y\u2010S","year":"2003","journal-title":"Brain Pathol"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00401-003-0687-0","article-title":"Primary lateral sclerosis: a rare upper\u2010motor\u2010predominant form of amyotrophic lateral sclerosis often accompanied by frontotemporal lobar degeneration with ubiquitinated neuronal inclusions. Report of an autopsy case and a review of the literature","volume":"105","author":"Tan C\u2010F","year":"2003","journal-title":"Acta Neuropathol"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2003.00544.x"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1789.2005.00599.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1789.2005.00599.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T09:12:44Z","timestamp":1706519564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1789.2005.00599.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,29]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1111\/j.1440-1789.2005.00599.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1789.2005.00599.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,29]]}}}