{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:20:16Z","timestamp":1762100416955},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,8,29]],"date-time":"2005-08-29T00:00:00Z","timestamp":1125273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>A 19\u2010year\u2010old female patient, who had exhibited esotropia, mild cerebellar ataxia, mild mental retardation, and cerebellar atrophy on magnetic resonance images at the age of 15, developed signs of acute encephalopathy, and thereafter died of disseminated intravascular coagulation on the day of her admission. Both her mother and sister suffered from attacks of hemiplegic migraine, mild mental retardation, and cerebellar ataxia. Neuropathological examinations revealed acute changes in the widespread cerebral cortex, chronic degenerative changes in the anterior lobe of the cerebellar vermis, axonal spheroids in the Goll's nucleus, pseudo\u2010calcinosis in the globus pallidus, and glial bundles in the cranial nerves. The most fascinating features were changes of Purkinje cells, such as cactuses (asteroid bodies, dendritic expansions), somatic sprouts, and torpedoes. These changes may be characteristic of familial hemiplegic migraine with cerebellar atrophy, as well as the other metabolic diseases, such as Menkes\u2019 kinky hair disease, infantile (Tay\u2013Sachs type) amaurotic idiocy, organic mercury intoxication, and mitochondrial encephalopathy, of which cases often exhibit such pathological changes of Purkinje cells. Therefore, familial hemiplegic migraine may share some metabolic abnormalities with the diseases mentioned above.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2005.00604.x","type":"journal-article","created":{"date-parts":[[2005,8,30]],"date-time":"2005-08-30T06:58:00Z","timestamp":1125385080000},"page":"228-234","source":"Crossref","is-referenced-by-count":16,"title":["Autopsy case of acute encephalopathy linked to familial hemiplegic migraine with cerebellar atrophy and mental retardation"],"prefix":"10.1111","volume":"25","author":[{"given":"Tatsuya","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Shimamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yume","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumimasa","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Inayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youichi","family":"Kameda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kuroiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81373-2"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450103"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1081"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10674"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-1055-9"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1961.00450110005002"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5377.225"},{"key":"e_1_2_7_9_2","first-page":"539","article-title":"T\u00f6dlicher Ausgang eines kindlichen Migr\u00e4neanfalles","volume":"33","author":"Holub V","year":"1965","journal-title":"Kinderarzt Prax"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6089.732"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1031"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0993-40"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-62"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110210"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420616"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050787"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050807"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00189-0"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.1.86"},{"key":"e_1_2_7_20_2","first-page":"198","article-title":"An autopsy case of spinocerebellar ataxia type 6 with mental symptoms of schizophrenia and dementia","volume":"18","author":"Tashiro H","year":"1999","journal-title":"Clin Neuropathol"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010000201"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00574-3"},{"key":"e_1_2_7_23_2","first-page":"764","article-title":"A sex\u2010linked recessive disorder with retardation of growth, peculiar hair, and focal cerebral and cerebellar degeneration","volume":"29","author":"Menkes JH","year":"1962","journal-title":"Pediatrics"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.27.1.41"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.17.4.235"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/63.4.365"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051023"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00114-8"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010000209"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.5.674"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-195011150-00003"},{"key":"e_1_2_7_32_2","first-page":"445","article-title":"A neuropathological study of severe mental retardation","volume":"23","author":"Morimatsu Y","year":"1983","journal-title":"Cong Anom"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1789.2005.00604.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1789.2005.00604.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T11:20:10Z","timestamp":1697282410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1789.2005.00604.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,29]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1111\/j.1440-1789.2005.00604.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1789.2005.00604.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,29]]}}}